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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 85 - 93 (9page)
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초록· 키워드
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The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation mark-etin stimulation. In addition, secretin induces sustained mitogen-acti-vated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP- MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis.
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참고문헌 (24)
참고문헌 신청
/ / Co-regulation of the mitogen-activated protein kinase and the 90-kDa ribosomal S6 kinase in PC12 cells
/ / Cyclic AMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor : 1257 ~ 61
/ / Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons and the central action of gut hormones : 2333 ~ 40
/ / Molecular charac-teristics and peptide specificity of vasoactive intestinal peptide receptors from rat cerebral cortex : 1469 ~ 75
/ / Sense and anti- sense transfection analysis of tau-function : 869 ~ 79
/ / Cyclic AMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor : 1257 ~ 61
/ / Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons and the central action of gut hormones : 2333 ~ 40
/ / Molecular charac-teristics and peptide specificity of vasoactive intestinal peptide receptors from rat cerebral cortex : 1469 ~ 75
/ / Sense and anti- sense transfection analysis of tau-function : 869 ~ 79
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