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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 201 - 207 (7page)
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AMPK (AMP-activated protein kinase) is highly conserved
in eukaryotes, where it functions primarily as
a sensor of cellular energy status. Recent studies indicate
that AMPK activation strongly suppresses cell
proliferation in non-malignant cells as well as in tumor
cells. In this study, quercetin activated AMPK in MCF
breast cancer cell lines and HT-29 colon cancer cells,
and this activation of AMPK seemed to be closely related
to a decrease in COX-2 expression. The application
of a COX-2 inhibitor or cox-2-/- cells supported the
idea that AMPK is an upstream signal of COX-2, and is
required for the anti-proliferatory and pro-apoptotic effects
of quercetin. The suppressive or growth inhibitory
effects of quercetin on COX-2 were abolished
by treating cancer cells with an AMPK inhibitor
Compound C. These results suggest that AMPK is crucial
to the anti-cancer effect of quercetin and that the
AMPK-COX-2 signaling pathway is important in quercetin-
mediated cancer control.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
AI-Fayez M / 2006 / Differential modulation of cyclooxygenase-mediated prostaglandinproduction by the putative cancer chemopreventive flavonoids tricin, apigenin and querceti
Ahn J / 2008 / The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways / Biochem Biophys Res Commun 373 : 545 ~ 549
Chun KS / 2004 / Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention / Biochem Pharmacol 68 : 1089 ~ 1100
Das D / 2007 / Chemoprevention of colorectal cancer / Digestion 76 : 51 ~ 67
Egert S / 2008 / Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans / J Nutr 138 : 1615 ~ 1621
Ahn J / 2008 / The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways / Biochem Biophys Res Commun 373 : 545 ~ 549
Chun KS / 2004 / Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention / Biochem Pharmacol 68 : 1089 ~ 1100
Das D / 2007 / Chemoprevention of colorectal cancer / Digestion 76 : 51 ~ 67
Egert S / 2008 / Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans / J Nutr 138 : 1615 ~ 1621
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