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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제12호
- 발행연도
- 2008.1
- 수록면
- 1,990 - 1,996 (7page)
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Astaxanthin has shown antioxidant, antitumor, and antiinflammatory
activities; however, its molecular action and
mechanism in the nervous system have yet to be elucidated.
We examined the in vitro effects of astaxanthin on the
production of nitric oxide (NO), as well as the expression
of inducible NO synthase (iNOS) and cyclooxygenase-2
(COX-2) in lipopolysaccharide (LPS)-stimulated BV2
microglial cells. Astaxanthin inhibited the expression
or formation of nitric oxide (NO), iNOS and COX-2 in
lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
Astaxanthin also suppressed the protein levels of iNOS
and COX-2 in LPS-stimulated BV2 microglial cells.
These results suggest that astaxanthin, probably due to its
antioxidant activity, inhibits the production of inflammatory
mediators by blocking iNOS and COX-2 activation or by
the suppression of iNOS and COX-2 degradation.
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참고문헌 (23)
참고문헌 신청
Benveniste, E. N. / 1997 / Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis / J. Mol. Med 75 : 165 ~ 173
Boujedaini, N. / 2001 / In vivo regulation of vasomotoricity by nitric oxide and prostanoids during gestation. Eur. J / Pharmacol 427 : 143 ~ 149
Boyle, E. A. / 1990 / Cellular immune response in multiple sclerosis plaques / Pathol 137 : 575 ~ 584
Chen, Y. C. / 2001 / Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase- 2 gene expressions by rutin, quercetin, a
Combs, C. K. / 2001 / β-Amyloid stimulation of microglia and monocytes results in TNF-alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis /
Boujedaini, N. / 2001 / In vivo regulation of vasomotoricity by nitric oxide and prostanoids during gestation. Eur. J / Pharmacol 427 : 143 ~ 149
Boyle, E. A. / 1990 / Cellular immune response in multiple sclerosis plaques / Pathol 137 : 575 ~ 584
Chen, Y. C. / 2001 / Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase- 2 gene expressions by rutin, quercetin, a
Combs, C. K. / 2001 / β-Amyloid stimulation of microglia and monocytes results in TNF-alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis /
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