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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,338 - 1,344 (7page)
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Purpose: It is often difficult to discriminate focal lymphocytic thyroiditis (FLT) or adenomatous hyperplasia (AH) from thyroid cancer if they both have suspicious ultrasound (US) findings. We aimed to make a predictive model of FLT from papillary thyroid cancer (PTC) in suspicious nodules with benign cytologic results.
Materials and Methods: We evaluated 214 patients who had undergone fine-needle aspiration biopsy (FNAB) and had shown thyroid nodules with suspicious US features. PTC was confirmed by surgical pathology. FLT and AH were confirmed through more than two separate FNABs. Clinical and biochemical findings, as well as US features, were evaluated.
Results: Of 214 patients, 100 patients were diagnosed with PTC, 55 patients with FLT, and 59 patients with AH. The proportion of elevated thyrotropin (TSH) levels (p=0.014) and thyroglobulin antibody (Tg-Ab) or thyroid peroxidase antibody (TPO-Ab) positivity(p<0.001) in the FLT group was significantly higher than that in the PTC group. Regarding US features, absence of calcification (p=0.006) and “diffuse thyroid disease” (DTD) pattern on US (p<0.001) were frequently seen in the FLT group. On multivariate analysis, Tg-Ab positivity, presence of a DTD pattern on US, and absence of calcification in nodules were associated with FLT with the best specificity of 99% and positive predictive value of 96%. In contrast, a taller than wide shape of nodules was the only variablesignificant for differentiating AH from PTC.
Conclusion: Suspicious thyroid nodules with cytologic benign results could be followed up with US rather than repeat FNAB, if patients exhibit Tg-Ab positivity, no calcifications in nodules, and a DTD pattern on US.
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참고문헌 (27)
참고문헌 신청
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guideli
Bastin S
Cappelli C / 2005 / Is the anteroposterior and transverse diameter ratio of nonpalpable thyroid nodules a sonographic criteria for recommending fineneedle aspiration cytolog
Cappelli C / 2006 / Thyroid nodule shape suggests malignancy / Eur J Endocrinol 155 : 27 ~ 31
Chernyavsky VS / 2012 / Is one benign fine needle aspiration enough? / Ann Surg Oncol 19 : 1472 ~ 1476
Bastin S
Cappelli C / 2005 / Is the anteroposterior and transverse diameter ratio of nonpalpable thyroid nodules a sonographic criteria for recommending fineneedle aspiration cytolog
Cappelli C / 2006 / Thyroid nodule shape suggests malignancy / Eur J Endocrinol 155 : 27 ~ 31
Chernyavsky VS / 2012 / Is one benign fine needle aspiration enough? / Ann Surg Oncol 19 : 1472 ~ 1476
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