Clinical Significance of Tumor Size in Papillary Thyroid Microcarcinoma: a Meta-Analysis

김수진; 김경식; 송영백; 성호경; 이규은; Sue K. Park

Clinical Significance of Tumor Size in Papillary Thyroid Microcarcinoma: a Meta-Analysis

Recommendations

Search

Type: Academic journal

Author: 김수진 김경식 송영백 성호경 이규은 Sue K. Park

Journal: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제18권 제2호 KCI Candidated Journals

Published: 2018.1

Pages: 142 - 154 (13page)

Usage

Clinical Significance of Tumor Size in Papillary Thyroid Microcarcinoma: a Meta-Analysis

Abstract· Keywords

Report Errors

Purpose: To determine whether the tumor size associtates with aggressive clinicopathologic features and tumor recurrence in patients with papillary thyroid microcarcinoma (PTMC) who had undergone thyroidectomy. Clinical significance of tumor size in patients with PTMC is still controversial. Methods: A search of PubMed, MEDLINE, and EMBASE identified the clinical studies that examined the association of subgroups classified by tumor size (5 mm) in surgical specimens with aggressive clinicopathologic features, and clinical outcomes between 1976 and 2017. Seven hundred twenty relevant studies were searched, and the authors selected 34 studies, including 12,134 PTMC cases. Random effects meta-analyses were performed using odds ratios (ORs) or relative risks (RRs) with 95% confidence intervals (CIs). Results: In 34 studies, compared with the patients with small PTMC, the patients with large PTMC had a higher risk of multifocality (OR, 1.97; 95% CI, 1.61–2.40; I2, 40.7%), extrathyroidal extension (OR, 3.42; 95% CI, 2.46–4.75; I2, 64.9%), and lymph node metastasis (OR, 2.45; 95% CI, 1.79–3.37; I2, 80.5%). In 10 studies, patient with large PTMC had 1.65-fold increased risk of locoregional recurrence (95% CI, 1.20–2.27; I2, 0.0%). Conclusion: This meta-analysis showed that tumor size in PTMC is associated with high-risk clinicopathologic characteristics and tumor recurrence. These findings may be helpful to decide treatment plans for patients with PTMC larger than 5 mm.

No content found

References (44)

Add References

Hedinger CE / 1988 / Histological Typing of Thyroid Tumours. 2nd ed / Springer-Verlag

Ito Y / 2006 / Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid / World J Surg 30:91~99

Jacquot-Laperriere S / 2007 / Papillary thyroid microcarcinoma: incidence and prognostic factors / Eur Arch Otorhinolaryngol 264:935~939

Roti E / 2008 / Thyroid papillary microcarcinoma: a descriptive and meta-analysis study / Eur J Endocrinol 159:659~673

Noguchi S / 2008 / Papillary microcarcinoma / World J Surg 32:747~753

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!