Prognostic Impact of Ultrasonography Features and 18F-Fluorodeoxyglucose Uptake in Patients With Papillary Thyroid Microcarcinoma

서지원; 황상현; Arthur Cho; 이혜선; 김은경; 문희정; 윤정현; 곽진영

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자료유형: 학술저널

저자정보: 서지원 황상현 Arthur Cho 이혜선 김은경 문희정 윤정현 곽진영

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제1호

발행연도: 2016.1

수록면: 62 - 69 (8page)

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Objectives. To evaluate the prognostic impact of ultrasonography (US) features and 18F-fluorodeoxyglucose (18F-FDG) uptake in patients with papillary thyroid microcarcinoma (PTMC). Methods. This study included 74 patients with a single PTMC diagnosed pathologically. Patients underwent total thyroidectomy, or near-total thyroidectomy and staging thyroid US and positron emission tomography (PET) were performed prior to surgery. US features of thyroid nodules were reviewed retrospectively and the maximum standard uptake value (SUV) of nodules was semiquantitatively analyzed on 18F-FDG PET/computed tomography (CT). Patients were followed-up for recurrence, which was defined as PTC on cytology results, elevated serum thyroglobulin (Tg) or anti-Tg antibody levels, or uptake on whole-body scintigraphy. We used univariate and multivariate analyses to evaluate whether poor prognostic outcomes were associated with US features or SUV values derived from PET/CT of nodules. In addition, subjects were divided into 2 groups for subgroup analyses: one with nodules equal to or larger than 5 mm and one with nodules smaller than 5 mm. Results. Among the 74 patients, there was no recurrence. Thus we evaluated the correlation between SUV value and US features with poor prognostic factors of PTMC which included extrathyroid extension, central and lateral lymph node (LN) metastasis. However no clinicopathologic factors were associated with extrathyroid extension, central LN metastasis, or lateral LN metastasis. Conclusion. In patients with PTMC, US features and SUV values on FDG-PET were not related to extrathyroid extension or LN metastasis. However, future studies with a larger sample size and longer follow-up should be performed to verify the results of this study.

#Keywords. Thyroid #Papillary Thyroid Microcarcinoma #Ultrasonography #Positron Emission Tomography

참고문헌 (30)

참고문헌 신청

Chen AY. / 2009 / Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005 / Cancer 115(16):3801~3807

Ito Y. / 2014 / Prognosis and growth activity depend on patient age in clinical and subclinical papillary thyroid carcinoma / Endocr J 61(3):205~213

Kucuk NO. / 2007 / Treatment for microcarcinoma of the thyroid : clinical experience / Clin Nucl Med 32(4):279~281

Roti E. / 2006 / Clinical and histological characteristics of papillary thyroid microcarcinoma : results of a retrospective study in 243 patients / J Clin Endocrinol Metab 91(6):2171~2178

김현지 / 2014 / Pathologic Spectrum of Lymphocytic Infiltration and Recurrence of Papillary Thyroid Carcinoma / Yonsei Medical Journal 55(4):879~885

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