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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 135 - 142 (8page)
- DOI
- 10.11106/ijt.2021.14.2.135
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초록· 키워드
오류제보하기
Background and Objectives: The clinical implications of the BRAF V600E mutation in papillary thyroid microcarcinoma(PTMC), defined as ≤1.0 cm of tumor size, remain controversial. We investigated the associationbetween the BRAF V600E mutation and PTMC recurrence in a retrospective cohort of patients with thyroid cancer.
Materials and Methods: This study included 2319 patients with PTMC (median age, 50 years [interquartile range(IQR), 41-57 years]) who underwent thyroid surgery from 2010 to 2019 at a single tertiary medical center. Themedian follow-up time was 75 months (IQR, 30-98 months). Tumor recurrence was confirmed by histological,cytological, radiographic, and biochemical criteria, combined with persistent and recurrent disease. Results: A totalof 60.2% (1395/2319) patients with PTMC had the BRAF V600E mutation. The tumor recurrence rate was 2.1%(19/924) in BRAF mutation-negative patients and 2.9% (41/1395) in BRAF mutation-positive patients, with ahazard ratio (HR) of 1.05 (95% confidence interval [CI], 0.61-1.84) after adjusting for clinicopathological riskfactors. Similar results were found in patients with high-risk PTMC (adjusted HR, 1.09; 95% CI, 0.56-2.11) whohad lymph node metastasis (LNM), extrathyroidal extension (ETE), or distant metastasis (DM) at diagnosis andin patients with low-risk PTMC (adjusted HR, 1.00; 95% CI, 0.35-2.83) who had no LNM, ETE, or DM. Conclusion:The finding that the BRAF V600E mutation was not associated with tumor recurrence in our cohort of Koreanpatients with PTMC, especially in patients with low-risk PTMC, suggests that its value in the prediction of diseaseprogression is limited.
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참고문헌 (30)
참고문헌 신청
Davies L / 2006 / Increasing incidence of thyroid cancer in the United States, 1973-2002 / JAMA 295(18):2164~2167
Cho BY / 2013 / Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades / Thyroid 23(7):797~804
Lim H / 2017 / Trends in thyroid cancer incidence and mortality in the United States, 1974-2013 / JAMA 317(13):1338~1348
Jeon MJ / 2018 / Decreasing disease-specific mortality of differentiated thyroid cancer in Korea : a multicenter cohort study / Thyroid 28(9):1121~1127
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
Cho BY / 2013 / Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades / Thyroid 23(7):797~804
Lim H / 2017 / Trends in thyroid cancer incidence and mortality in the United States, 1974-2013 / JAMA 317(13):1338~1348
Jeon MJ / 2018 / Decreasing disease-specific mortality of differentiated thyroid cancer in Korea : a multicenter cohort study / Thyroid 28(9):1121~1127
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
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