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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 790 - 799 (10page)
- DOI
- https://doi.org/10.3803/EnM.2021.1034
이용수
초록· 키워드
오류제보하기
Background: This study aimed to assess the effects of iodine intake, thyroid function, and their combined effect on the risk of papillary thyroid cancer (PTC) and papillary thyroid microcarcinoma (PTMC).
Methods: A case-control study was conducted including 500 community-based controls who had undergone a health check-up, and446 overall PTC cases (209 PTC and 237 PTMC) from the Thyroid Cancer Longitudinal Study. Urinary iodine concentration (UIC),was used as an indicator of iodine intake, and serum for thyroid function. The risk of PTC and PTMC was estimated using unconditional logistic regression.
Results: Excessive iodine intake (UIC ≥220 μg/gCr) was associated with both PTC (odds ratio [OR], 18.13 95% confidence interval [CI], 8.87 to 37.04) and PTMC (OR, 8.02; 95% CI, 4.64 to 13.87), compared to adequate iodine intake (UIC, 85 to 219 μg/gCr).
Free thyroxine (T4) levels ≥1.25 ng/dL were associated with PTC (OR, 1.97; 95% CI, 1.36 to 2.87) and PTMC (OR, 2.98; 95% CI,2.01 to 4.41), compared to free T4 levels of 0.7 to 1.24 ng/dL. Individuals with excessive iodine intake and high free T4 levels had agreatly increased OR of PTC (OR, 43.48; 95% CI, 12.63 to 149.62), and PTMC (OR, 26.96; 95% CI, 10.26 to 70.89), compared toindividuals with adequate iodine intake and low free T4 levels.
Conclusion: Excessive iodine intake using creatinine-adjusted UIC and high free T4 levels may have a synergistic effect on PTCand PTMC. Considering both iodine intake and thyroid function is important to assess PTC and PTMC risk.
목차
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참고문헌 (7)
참고문헌 신청
정혜림 / 2014 / Iodine and thyroid function / Annals of Pediatric Endocrinology & Metabolism 19(1):8~12
Xin Sun / 2014 / Effects of Increased Iodine Intake on Thyroid Disorders / Endocrinology and Metabolism 29(3):240~247
Arija V / 2015 / Biases and adjustments in nutritional assessments from dietary questionnaires / Nutr Hosp 31(Suppl 3):113~118
Jonghwa Ahn / 2020 / Association between urinary sodium levels and iodine status in Korea / The Korean Journal of Internal Medicine 35(2):392~399
정재훈 / 2020 / Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015) / Endocrinology and Metabolism 35(1):7~13
Xin Sun / 2014 / Effects of Increased Iodine Intake on Thyroid Disorders / Endocrinology and Metabolism 29(3):240~247
Arija V / 2015 / Biases and adjustments in nutritional assessments from dietary questionnaires / Nutr Hosp 31(Suppl 3):113~118
Jonghwa Ahn / 2020 / Association between urinary sodium levels and iodine status in Korea / The Korean Journal of Internal Medicine 35(2):392~399
정재훈 / 2020 / Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015) / Endocrinology and Metabolism 35(1):7~13
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