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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective : The purpose of this study was to examine the effects of adjunctive aripiprazole versus bupropion on specific symptoms of depression.
Methods : Data were from 6-week, randomized, prospective, open-label multi-center study in 103 patients with major depressive disorders. Participants were randomized to receive aripiprazole (2.5-10 mg/ day) or bupropion (150-300 mg/day) for 6 weeks. Change in four subscales of the 17-item Hamilton Depression Rating Scale (HAM-D17) that capture core depression symptoms was determined, and change in individual HAM-D17 items was also assessed. Changes in three composite subscales-anxiety, insomnia, and drive were also examined.
Results : Within-group change in the four core subscales was large [effect size (ES)=1.30-1.47] and it was similar to that in the HAM-D17 total score. Differences between aripiprazole and bupropion were significant for each of the four core subscales and the HAM-D17 total score favored aripiprazole (p＜0.001). On three composite scales, both treatments caused substantial changes in anxiety (within-group ES=1.10 (aripiprazole) vs. 1.00 (bupropion)], insomnia (ES=0.75 vs 0.50), and drive (ES=1.17 vs 1.15).
Conclusion : This results suggested that both aripiprazole and bupropion adjunctive therapies with selective serotonin reuptake inhibitors resulted in significant and clinically meaningful changes in core symptom subscales for depression. (Anxiety and Mood 2017;13(2):66-73)
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참고문헌 (24)
참고문헌 신청
Association AP / 2000 / Practice guideline for the treatment of patients with major depressive disorder (revision) / Am J Psychiatry 157 : 1 ~ 45
Bech P / 1975 / Quantitative rating of depressive states / Acta Psychiatr Scand 51 : 161 ~ 170
Cheon EJ / 2017 / Comparison of the Efficacy and Safety of Aripiprazole Versus Bupropion Augmentation in Patients With Major Depressive Disorder Unresponsive to Selective Se
Cohen J. / 1988 / Statistical power analysis for the behavioral sciences / Lawrence Earlbaum Associates : 20 ~ 26
Evans KR / 2004 / An item response analysis of the Hamilton Depression Rating Scale using shared data from two pharmaceutical companies / J Psychiatr Res 38 : 275 ~ 284
Bech P / 1975 / Quantitative rating of depressive states / Acta Psychiatr Scand 51 : 161 ~ 170
Cheon EJ / 2017 / Comparison of the Efficacy and Safety of Aripiprazole Versus Bupropion Augmentation in Patients With Major Depressive Disorder Unresponsive to Selective Se
Cohen J. / 1988 / Statistical power analysis for the behavioral sciences / Lawrence Earlbaum Associates : 20 ~ 26
Evans KR / 2004 / An item response analysis of the Hamilton Depression Rating Scale using shared data from two pharmaceutical companies / J Psychiatr Res 38 : 275 ~ 284
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