지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives ZZThere is evidence that Hypothalamic-Pituitary-Adrenocortical (HPA) system dysregulation plays a role in the pathophysiology of depression. However which psychiatric symptoms are related to HPA system dysregulation has not been studied well. The primary aim of this study was to investigate which symptom components of the Hamilton Depression Rating Scale (HAM-D) are related to HPA system dysregulation in Korean psychiatric outpatients. The secondary aim was to find other variables that have association with HAM-D components. MethodsZZThis study was a retrospective review of the charts of outpatients who first visited Samsung Medical Center Depression Clinic between July 2012 and October 2013. Among them those who checked the plasma cortisol level and HAM-D within one week of their first visit were selected. Fifty nine patients were selected. The HAM-D was divided into four components, including depression, anxiety, insomnia, and somatic components. Multiple regression of cortisol level was used for four subscales. \ResultsZZSignificant positive correlations were observed between the plasma cortisol level and depression component of HAM-D (beta=0.251, p=0.049). Age also showed negative correlation with the depression component of HAM-D (beta=-0.427, p=0.002). However anxiety, insomnia and somatic components of HAM-D did not show correlation with plasma cortisol level. ConclusionZZOur study suggests that in Korean depression clinic outpatients, the depression component of HAM-D is related to plasma cortisol level.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Akil HA / 1995 / Psychopharmacology:the fourth generation of progress / Raven Press : 773 ~ 785
Burke HM / 2005 / Depression and cortisol responses to psychological stress: a meta-analysis / Psychoneuroendocrinology 30 : 846 ~ 856
Cho MJ / / The epidemiological survey of mental disorders in Korea
Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267 : 1244 ~ 1252
Deuschle M / 1997 / Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls / J Clin Endocrinol Metab 8
Burke HM / 2005 / Depression and cortisol responses to psychological stress: a meta-analysis / Psychoneuroendocrinology 30 : 846 ~ 856
Cho MJ / / The epidemiological survey of mental disorders in Korea
Chrousos GP / 1992 / The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis / JAMA 267 : 1244 ~ 1252
Deuschle M / 1997 / Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls / J Clin Endocrinol Metab 8
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