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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제3호
- 발행연도
- 2019.1
- 수록면
- 400 - 408 (9page)
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초록· 키워드
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Objective: This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. Methods: Adolescent male Sprague-Dawley rats were injected intraperitoneally with aripiprazole, risperidone, or vehicle control for 3 weeks (postnatal day 36‒56). After a 2-week washout period, locomotion, anxiety, and spatial working memory were evaluated in adulthood (postnatal day 71‒84), using an open field test, elevated plus maze, and Y-maze, respectively. In addition, we assessed D2R levels in the dorsolateral and medial prefrontal cortex (PFC), dorsal and ventral striatum, and hippocampus using western blot analysis. Results: Spontaneous alternation performance (SAP) in the Y-maze, a measure of spatial working memory, differed significantly among the 3 groups (F = 3.89, p = 0.033). A post-hoc test confirmed that SAP in the aripiprazole group was significantly higher than that in the risperidone group (post-hoc test p = 0.013). D2R levels in the medial PFC (F = 8.72, p = 0.001) and hippocampus (F = 13.54, p ＜ 0.001) were different among the 3 groups. D2R levels in the medial PFC and hippocampus were significantly lower in the aripiprazole-treated rats than that in the risperidone- treated rats (post-hoc test p = 0.025 and p ＜ 0.001, respectively) and controls (post-hoc test p ＜ 0.001, all). Conclusion: This study showed that aripiprazole treatment in adolescence could influence cognitive function and dopaminergic neurotransmission into early adulthood.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Olfson M / 2012 / National trends in the office-based treatment of children, adolescents, and adults with antipsychotics / Arch Gen Psychiatry 69:1247~1256
Olfson M / 2015 / Treatment of young people with antipsychotic medications in the United States / JAMA Psychiatry 72:867~874
Correll CU / 2011 / Developments in pediatric psychopharmacology : focus on stimulants, antidepressants, and antipsychotics / J Clin Psychiatry 72:655~670
Correll CU / 2015 / Antipsychotic use in youth without psychosis : a double-edged sword / JAMA Psychiatry 72:859~860
Bardgett ME / 2013 / Adult rats treated with risperidone during development are hyperactive / Exp Clin Psychopharmacol 21:259~267
Olfson M / 2015 / Treatment of young people with antipsychotic medications in the United States / JAMA Psychiatry 72:867~874
Correll CU / 2011 / Developments in pediatric psychopharmacology : focus on stimulants, antidepressants, and antipsychotics / J Clin Psychiatry 72:655~670
Correll CU / 2015 / Antipsychotic use in youth without psychosis : a double-edged sword / JAMA Psychiatry 72:859~860
Bardgett ME / 2013 / Adult rats treated with risperidone during development are hyperactive / Exp Clin Psychopharmacol 21:259~267
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