지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : The purpose of this study was to examine effects of adjunctive aripiprazole versus bupropion, on depressive symptoms of female depression. Methods : Sixty six female patients with major depressive disorders were enrolled from a six-week, randomized prospective open-label multi-center study. Participants were randomized to receive aripiprazole (2.5-10 mg/day) or bupropion (150-300 mg/day). Montgomery Asberg Depression Rating Scale, 17-item Hamilton Depression Rating scale (HAM-D17), Iowa Fatigue Scale, Drug-Induced Extrapyramidal Symptoms Scale, Psychotropic-Related Sexual Dysfunction Questionnaire scores, and Clinical Global Impression-Severity (CGI-S) were obtained at baseline and after one, two, four, and six weeks. Changes on individual items of HAM-D17 were assessed as well as on composite scales (anxiety, insomnia and drive), and on four core subscales that capture core depression symptoms. Results : Overall, both treatments improved depressive symptoms, without causing serious adverse events. There were significant differences in the HAM-D17 total score (p=0.046) and CGI-S (p=0.004), between aripiprazole and bupropion augmentation, favoring aripiprazole over bupropion. Aripiprazole revealed significantly greater effect size in depressed mood (p=0.006), retardation (p=0.005), anxiety psychic (p=0.032), and general somatic symptom (p=0.01). Conclusion : While both treatments were effective, results of this study suggested that aripiprazole may be preferable, in treating general and core symptoms of female depression.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Weissman MM / 1993 / Sex differences in rates of depression: cross-national perspectives / J Affect Disord 29:77~84
Bijl RV / 2002 / Gender and age-specific first incidence of DSM-III-R psychiatric disorders in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS) / Soc Psychiatry Psychiatr Epidemiol 37:372~379
Oldehinkel AJ / 2011 / Sensitivity to the depressogenic effect of stress and HPA-axis reactivity in adolescence: a review of gender differences / Neurosci Biobehav Rev 35:1757~1770
Schuch JJ / 2014 / Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety / J Affect Disord 156:156~163
Silverstein B / 2011 / Poor response to antidepressant medication of patients with depression accompanied by somatic symptomatology in the STAR*D Study / Psychiatry Res 187:121~124
Bijl RV / 2002 / Gender and age-specific first incidence of DSM-III-R psychiatric disorders in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS) / Soc Psychiatry Psychiatr Epidemiol 37:372~379
Oldehinkel AJ / 2011 / Sensitivity to the depressogenic effect of stress and HPA-axis reactivity in adolescence: a review of gender differences / Neurosci Biobehav Rev 35:1757~1770
Schuch JJ / 2014 / Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety / J Affect Disord 156:156~163
Silverstein B / 2011 / Poor response to antidepressant medication of patients with depression accompanied by somatic symptomatology in the STAR*D Study / Psychiatry Res 187:121~124
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
노인 우울증 환자에서 Aripiprazole과 Bupropion 부가요법의 효과 및 안전성 비교 : 사후분석연구
생물치료정신의학
2019 .06
-
세로토닌 재흡수 억제제에 대한 아리피프라졸 및 부프로피온 부가요법의 우울증 세부증상에 대한 효과 비교 : 다기관, 개방표지, 무작위 연구
대한불안의학회지
2017 .01
-
빈곤 여성 자활근로자의 우울과 신체화 증상이 구강 자각증상에 미치는 영향
한국구강보건과학회지
2024 .03
-
우울증 센터 내원 초진 환자에서 혈중 코티솔 농도와 해밀턴 우울 평가 척도의 우울증상 항목과의 관계
신경정신의학
2015 .01
-
노인성 우울증 환자와 정상 노인에서 인지기능의 비교 및 우울증 증상 변화와의 관련성 평가
노인정신의학
2018 .01
-
Bupropion for Interferon-Alpha-Induced Depression in Patients with Hepatitis C Viral Infection: An Open-Label Study
PSYCHIATRY INVESTIGATION
2015 .01
-
호텔 서비스 근로자의 심리적 요인과 주관적 구강증상의 관련성: 신체화 증상의 매개효과 중심
한국구강보건과학회지
2023 .06
-
The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study
Clinical Psychopharmacology and Neuroscience
2019 .01
-
두경부암 환자의 우울과 불안증상 유무에 따른 증상의 심각성
성인간호학회지
2016 .04
-
Do Somatic Symptoms Predict the Severity of Depression? A Validation Study of the Korean Version of the Depression and Somatic Symptoms Scale
Journal of Korean Medical Science
2016 .01
-
우울증 대상자의 정신 상담 경험 여부 예측 모형
한국보건간호학회지
2023 .04
-
Associations Among Plasma Stress Markers and Symptoms of Anxiety and Depression in Patients with Breast Cancer Following Surgery
PSYCHIATRY INVESTIGATION
2018 .01
-
The Change of Suicidal Ideation Over a 12-Week Naturalistic Treatment of Depression: Comparison Between Young People and Older Adults
PSYCHIATRY INVESTIGATION
2023 .01
-
페그인터페론 치료를 받는 만성바이러스성 간염 환자의불안에 관한 연구
신경정신의학
2015 .01
-
The Clinical Characteristics and Manifestation of Anxious Depression Among Patients With Major Depressive Disorders-Results From a Taiwan Multicenter Study
PSYCHIATRY INVESTIGATION
2024 .06
-
Identification of Central Symptoms in Depression of Older Adults With the Geriatric Depression Scale Using Network Analysis and Item Response Theory
PSYCHIATRY INVESTIGATION
2021 .11
-
만성 폐쇄성 폐질환 환자의 증상경험과 우울의 관계에 미치는 극복력의 매개효과
성인간호학회지
2015 .08
-
Incidence and Course of Depression in Patients with Alzheimer’s Disease
PSYCHIATRY INVESTIGATION
2017 .01
-
Clinical Significance of the Number of Depressive Symptoms in Major Depressive Disorder: Results from the CRESCEND Study
Journal of Korean Medical Science
2016 .01
-
농촌지역 우울증 고위험군에서 만성 의학적 질환과 우울증상 : 1년 추적관찰 연구
생물치료정신의학
2019 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0