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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 142 - 145 (4page)
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초록· 키워드
오류제보하기
Interferon (IFN)-α therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-α-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores≤7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Ahmed F / 2011 / Seizures during pegylated interferon and ribavirin therapy for chronic Hepatitis C: observations from the WIN-R trial / J Clin Gastroenterol 45 : 286 ~ 292
Asnis GM / 2005 / Interferon-induced depression: strategies in treatment / Prog Neuropsychopharmacol Biol Psychiatry 29 : 808 ~ 818
Brustolim D / 2006 / A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma
Capuron L / 2002 / Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions / Neuropsychopharmacology
Fava M / 2005 / 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL / Prim Care Companion J Clin Psychiatry 7 : 106 ~ 113
Asnis GM / 2005 / Interferon-induced depression: strategies in treatment / Prog Neuropsychopharmacol Biol Psychiatry 29 : 808 ~ 818
Brustolim D / 2006 / A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma
Capuron L / 2002 / Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions / Neuropsychopharmacology
Fava M / 2005 / 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL / Prim Care Companion J Clin Psychiatry 7 : 106 ~ 113
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