지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 76 - 81 (6page)
이용수
초록· 키워드
오류제보하기
Objective: This study compared the safety and efficacy of Safacto® versus xyntha® in patients with severe hemophilia A. Methods: Thirty-three male patients with severe hemophilia A were randomly divided into two groups. Seventeen patients received Safacto® and 16 patients received Xyntha® for four consecutive times. The dosage of FVIII was 40-50 IU/kg for each injection. Plasma level of FVIII activity was evaluated before every injection, 15 minutes after the injection and one month after the start of the trial. The rate of factor VIII activity, pain and joint motion were also assessed before and after the treatment. Results: Plasma level of FVIII clotting activity in Safacto® and Xyntha® were 1.96±0.5 IU/dl and 1.63±0.5 IU/dl and increased to 88.84±25.2 IU/dl and 100.09±17.8 IU/ dl, respectively (P<0.001). Pain score and range of motion improvement were 9.3±0.9 and 8.7±0.1 in Safacto® (P=0.17); and 9.4±0.8 and 8.8±0.3 in Xyntha® (P=0.35), respectively. No allergic or other unfavorable reactions was observed with either of the preparations. Conclusion: This study showed that Safacto® has a favorable efficacy and safety profile.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Mannucci PM / 2001 / The hemophili-as--from royal genes to gene therapy / N Engl J Med 344(23):1773~1779
White GC 2nd / 2001 / Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Trombosis and Haemostasis / Tromb Haemost 85(3):560
Cheraghali A / 2012 / Cost effectiveness of Iran national plasma contract fractionation program / DARU Journal of Pharmaceutical Sciences 20(1):63
Faranoush M / 2011 / Patients Perspective in Plasma Products (Focus on Hemophilia) / Iranian Journal of Blood and Cancer 3(3):171~175
Cheraghali AM / 2009 / Economical impact of plasma fractionation project in Iran on affordability of plasma-derived medicines / Transfusion Medicine 19(6):363~368
White GC 2nd / 2001 / Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Trombosis and Haemostasis / Tromb Haemost 85(3):560
Cheraghali A / 2012 / Cost effectiveness of Iran national plasma contract fractionation program / DARU Journal of Pharmaceutical Sciences 20(1):63
Faranoush M / 2011 / Patients Perspective in Plasma Products (Focus on Hemophilia) / Iranian Journal of Blood and Cancer 3(3):171~175
Cheraghali AM / 2009 / Economical impact of plasma fractionation project in Iran on affordability of plasma-derived medicines / Transfusion Medicine 19(6):363~368
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Rare Case of Acquired Hemophilia A in Adolescents and Young Adults
Clinical Pediatric Hematology-Oncology
2022 .04
-
Six-Year-Old Girl with Porcelain Gallbladder
Journal of Korean Medical Science
2019 .01
-
The activity of factor VIII and IX of cord blood at mid-trimester in fetuses without hemophilia
Journal of genetic medicine
2016 .01
-
Clinical data on treatment regimen and use of medication among patients with hemophilia B in Korea
Blood Research
2024 .09
-
Impact of ABO blood group antigens on residual factor VIII levels and risk of inhibitor development in hemophilia A
Blood Research
2023 .03
-
Evaluation of FVIII pharmacokinetic profiles in Korean hemophilia A patients assessed with myPKFiT: a retrospective chart review
Blood Research
2024 .09
-
The Big Vitamin D Mistake
예방의학회지
2017 .07
-
Different Degeneration Patterns of Paraspinal Muscles Between Double-Level and Single-Level Lumbar Spondylolisthesis: An Magnetic Resonance Imaging Analysis of 140 Patients
Neurospine
2024 .09
-
Maintenance Dose of Vitamin D: How Much Is Enough?
대한골대사학회지
2018 .01
-
Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease
Vascular Specialist International
2021 .09
-
Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma
Gut and Liver
2020 .01
-
FVIII inhibitor surveillance in children with hemophilia A in Indonesia: a report from the Indonesian Pediatric Hematology-Oncology Working Group
Blood Research
2022 .12
-
Relationship between low hemoglobin levels and mortality in patients with septic shock
Acute and Critical Care
2019 .01
-
A Case Report of Very Severe Hyperphosphatemia (19.3mg/dL) in a Uremic Patient Taking Honey and Persimmon Vinegar
Electrolytes & Blood Pressure
2021 .12
-
A Severe Hepatotoxicity by Antituberculosis Drug, and its Recovery in Oriental Hospital
대한한의학회지
2016 .06
-
Efficacy, Safety, and Pharmacokinetics of Beroctocog Alfa in Patients Previously Treated for Hemophilia A
Yonsei Medical Journal
2015 .01
-
An analysis of Y-chromosome microdeletion in infertile Korean men with severe oligozoospermia or azoospermia
Investigative and Clinical Urology
2024 .01
-
Verification and Comparison of Chromogenic Factor VIII Activity Assays in Patients With Hemophilia Treated With and Without Emicizumab
Annals of Laboratory Medicine
2023 .01
-
Factors Associated with Pain Following Intravitreal Injections
Korean Journal of Ophthalmology
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0