지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 26 - 26 (1page)
- DOI
- 10.5758/vsi.210010
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초록· 키워드
오류제보하기
Purpose: We aimed to evaluate the impact of intrinsic coagulation factors and hemostatic markers of endothelial dysfunction on complications in patients with atherosclerotic peripheral arterial disease (PAD).
Materials and Methods: This prospective study enrolled 120 PAD patients at Fontaine stages 2b to 3 who underwent open surgical, endovascular, or conservative treatment. Coagulation factors (FVIII, FIX, and FXI) and endothelial hemostatic markers, including von Willebrand factor (vWF) activity and level, soluble endothelial protein C receptor, and plasminogen activator inhibitor-1 (PAI-1) levels, were assessed.
Results: At 3 months after open bypass grafting, activity of FVIII significantly increased from a median of 175% to 233% (P<0.001). At 3 months after endovascular treatment, the activities of FVIII, FIX, and FXI significantly increased from medians of 157%, 180%, and 156% to 184%, 218%, and 181%, respectively (P<0.05). Six patients with increased FVIII activity developed bypass graft thrombosis. Four patients in the endovascular group and three patients in the conservative treatment group with increased activity of vWF developed myocardial infarction (P=0.049). The subjects who developed restenosis had increased vWF activity (P=0.023) and decreased nitric oxide metabolite levels (P=0.003). Three subjects who received conservative treatment and developed PAD progression at 12 months had increased PAI-1 activity (P=0.028).
Conclusion: Patients with advanced PAD had a hypercoagulable status, and performance of open or endovascular revascularization was associated with further hypercoagulability. Increased activity of coagulation factors and altered levels of hemostatic markers of endothelial dysfunction were associated with PAD complications such as graft thrombosis, myocardial infarction, disease progression, and restenosis.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Singh P / 2017 / Peripheral interventions and antiplatelet therapy : role in current practice / World J Cardiol 9:583~593
Katsanos K / 2017 / Peripheral stent thrombosis leading to acute limb ischemia and major amputation : incidence and risk factors in the aortoiliac and femoropopliteal arteries / Cardiovasc Intervent Radiol 40:351~359
Sana TR / 2005 / Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines / Cytokine 29:256~269
Mohan Rao LV / 2014 / Endothelial cell protein C receptor : a multiliganded and multifunctional receptor / Blood 124:1553~1562
Delvaeye M / 2009 / Coagulation and innate immune responses : can we view them separately / Blood 114:2367~2374
Katsanos K / 2017 / Peripheral stent thrombosis leading to acute limb ischemia and major amputation : incidence and risk factors in the aortoiliac and femoropopliteal arteries / Cardiovasc Intervent Radiol 40:351~359
Sana TR / 2005 / Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines / Cytokine 29:256~269
Mohan Rao LV / 2014 / Endothelial cell protein C receptor : a multiliganded and multifunctional receptor / Blood 124:1553~1562
Delvaeye M / 2009 / Coagulation and innate immune responses : can we view them separately / Blood 114:2367~2374
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