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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 89 - 94 (6page)
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Purpose: Molecular genetic analysis is the main approach used for prenatal diagnosis of hemophilia A and B. However, in certain cases, such analysis is uninformative. In such situations, direct measurement of fetal coagulation factor levels is still the best option, and it may be the only option in some cases. This study was conducted to determine the normal ranges of mid-trimester cord blood factor VIII (FVIII) and IX (FIX) in a Korean population. Materials and Methods: Twenty-six FVIII samples and 29 FIX samples were assayed in fetal cord blood acquired by ultrasound-guided cordocentesis. Sampling was conducted during gestational ages of 19-24 weeks. Results: The mean and standard deviations for FVIII and FIX activity were $45.5{\pm}30.5%$ and $19.9{\pm}12.2%$, respectively. Ranges for FVIII and FIX were 1.5-125.0% and 6.0-52.0%, respectively. Conclusion: Our study revealed the normal ranges and lowest level of factor VIII and factor IX in non-affected normal fetus by fetal cord blood sampling during the mid-trimester in a Korea population. The factor assay of the fetal cord blood is invasive but feasible and provides important basic data related to hemophilia.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Dahlbäck B / 2000 / Blood coagulation / Lancet 355:1627~1632
Hwang SH / 2009 / Profiling of factor VIII mutations in Korean haemophilia A / Haemophilia 15:1311~1317
White GC 2nd / 2001 / Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis / Thromb Haemost 85:560
Stonebraker JS / 2010 / A study of variations in the reported haemophilia A prevalence around the world / Haemophilia 16:20~32
Shetty S / 2007 / Robustness of factor assays following cordocentesis in the prenatal diagnosis of haemophilia and other bleeding disorders / Haemophilia 13:172~177
Hwang SH / 2009 / Profiling of factor VIII mutations in Korean haemophilia A / Haemophilia 15:1311~1317
White GC 2nd / 2001 / Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis / Thromb Haemost 85:560
Stonebraker JS / 2010 / A study of variations in the reported haemophilia A prevalence around the world / Haemophilia 16:20~32
Shetty S / 2007 / Robustness of factor assays following cordocentesis in the prenatal diagnosis of haemophilia and other bleeding disorders / Haemophilia 13:172~177
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