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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제1호
- 발행연도
- 2015.1
- 수록면
- 17 - 23 (7page)
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초록· 키워드
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Background and PurposeThe “closing-in” phenomenon refers to the tendency to copy near or overlap a model while performing figure-copying tasks. The mechanisms underlying the closing-in phenomenon have not been fully elucidated, and previous studies only investigated the mechanisms through neuropsychological tests. We investigated the neuroanatomical correlates of the closing-in phenomenon using voxel-based morphometry (VBM).
MethodsThirty-eight patients diagnosed with probable Alzheimer’s disease (AD) and 21 normal controls were included. All subjects underwent neuropsychological testing to diagnose dementia and magnetization prepared rapid acquisition gradient echo brain magnetic resonance imaging for the voxel-based statistical analysis. The subjects were asked to copy the modified Luria’s alternating squares and triangles to quantify the closing-in phenomenon. We applied SPM8 for the VBM analysis to detect gray matter loss associated with the closing-in phenomenon.
ResultsThe patients with probable AD showed a higher closing-in score than that of the normal control subjects (p<0.0001). The VBM analysis revealed more parietal and temporal atrophy in the patients with AD than that in the normal control group. Moreover, atrophy of the orbito-frontal area was associated with the closing-in phenomenon.
ConclusionsThe closing-in phenomenon is dysfunction while performing figure-copying tasks and is more common in patients with AD. The analysis of the orbito-frontal area, which is associated with inhibiting primitive reflexes, revealed that the closing-in phenomenon is an imitation behavior commonly observed in patients with frontal lobe damage.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ambron E / 2009 / Closing-in behaviour in fronto-temporal dementia / J Neurol 256 : 1004 ~ 1006
Ashburner J / 2000 / Voxel-based morphometry--the methods / Neuroimage 11 (6 Pt 1) : 805 ~ 821
Busatto GF / 2008 / Voxel-based morphometry in Alzheimer’s disease / Expert Rev Neurother 8 : 1691 ~ 1702
Chin J / 2005 / The closing-in phenomenon in Alzheimer’s disease and vascular dementia / J Clin Neurol 1 : 166 ~ 173
Choi SH / 2001 / Estimating the validity of the Korean version of Expanded Clinical Dementia Rating (CDR) Scale / J Korean Neurol Assoc 19 : 585 ~ 591
Ashburner J / 2000 / Voxel-based morphometry--the methods / Neuroimage 11 (6 Pt 1) : 805 ~ 821
Busatto GF / 2008 / Voxel-based morphometry in Alzheimer’s disease / Expert Rev Neurother 8 : 1691 ~ 1702
Chin J / 2005 / The closing-in phenomenon in Alzheimer’s disease and vascular dementia / J Clin Neurol 1 : 166 ~ 173
Choi SH / 2001 / Estimating the validity of the Korean version of Expanded Clinical Dementia Rating (CDR) Scale / J Korean Neurol Assoc 19 : 585 ~ 591
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