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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 516 - 522 (7page)
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초록· 키워드
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ObjectiveaaComorbid depression is common in patients with Alzheimer’s disease (AD). An increase in white matter lesions (WMLs) has been associated with depression in both elderly individuals with normal cognition and patients with Alzheimer’s disease. We investigated whether the severity and location of WMLs influence the association between WMLs and comorbid depression in AD.
MethodsaaWe enrolled 93 AD patients from Seoul National University Bundang Hospital. We administered both the Mini International Neuropsychiatric Inventory (MINI) and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K) clinical and neuropsychological battery. Subjects also underwent brain magnetic resonance imaging (MRI). We diagnosed AD according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association. We diagnosed depressive disorders according to the DSM-IV diagnostic criteria, and evaluated the severity of depressive symptoms using the Korean version of the Geriatric Depression Scale (GDS-K). We quantified the WML volumes from the brain MRI using a fully automated segmentation algorithm.
ResultsaaThe log of the WML volume in the frontal lobe was significantly associated with depressive disorders (odds ratio=1.905, 95% CI=1.027–3.533, p=0.041), but not with the severity of depressive symptoms as measured by the GDS-K.
ConclusionaaThe WML volume in the frontal lobe conferred a risk of comorbid depressive disorders in AD, which implies that comorbid depression in AD may be attributed to vascular causes.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alexopoulos GS / 1997 / ‘Vascular depression’ hypothesis / Arch Gen Psychiatry 54 : 915 ~ 922
Almkvist O / 1992 / White-matter hyperintensity and neuropsychological functions in dementia and healthy aging / Arch Neurol 49 : 626 ~ 632
Barber R / 1999 / White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging / J Neurol Neuro
Clark LM / 1998 / Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer’s disease / Biol Psychiatry 44 : 592 ~ 599
Diaz JF / 1991 / Improved recognition of leukoaraiosis and cognitive impairment in Alzheimer’s disease / Arch Neurol 48 : 1022 ~ 1025
Almkvist O / 1992 / White-matter hyperintensity and neuropsychological functions in dementia and healthy aging / Arch Neurol 49 : 626 ~ 632
Barber R / 1999 / White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging / J Neurol Neuro
Clark LM / 1998 / Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer’s disease / Biol Psychiatry 44 : 592 ~ 599
Diaz JF / 1991 / Improved recognition of leukoaraiosis and cognitive impairment in Alzheimer’s disease / Arch Neurol 48 : 1022 ~ 1025
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