지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 92 - 102 (11page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThis study proposes an automated diagnostic method to classify patients with Alzheimer’s disease (AD) of degenerative etiology using magnetic resonance imaging (MRI) markers.
MethodsaaTwenty-seven patients with subjective memory impairment (SMI), 18 patients with mild cognitive impairment (MCI), and 27 patients with AD participated. MRI protocols included three dimensional brain structural imaging and diffusion tensor imaging to assess the cortical thickness, subcortical volume and white matter integrity. Recursive feature elimination based on support vector machine (SVM) was conducted to determine the most relevant features for classifying abnormal regions and imaging parameters, and then a factor analysis for the top-ranked factors was performed. Subjects were classified using nonlinear SVM.
ResultsaaMedial temporal regions in AD patients were dominantly detected with cortical thinning and volume atrophy compared with SMI and MCI patients. Damage to white matter integrity was also accredited with decreased fractional anisotropy and increased mean diffusivity (MD) across the three groups. The microscopic damage in the subcortical gray matter was reflected in increased MD. Classification accuracy between pairs of groups (SMI vs. MCI, MCI vs. AD, SMI vs. AD) and among all three groups were 84.4% (±13.8), 86.9% (±10.5), 96.3% (±4.6), and 70.5% (±11.5), respectively.
ConclusionaaThis proposed method may be a potential tool to diagnose AD pathology with the current clinical criteria
목차
등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Kang Y / 1997 / A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients / J Korean Neurol Assoc 15:300~308
McKhann G / 1984 / Clinical diagnosis of Alzheimer’s disease Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease / Neurology 34:939~944
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
Choi YH / 2006 / Validity of Korean version of the Mini-International Neuropsychiatric Interview / Anxiety Mood 2:50~55
Fischl B / 2002 / Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain / Neuron 33:341~355
McKhann G / 1984 / Clinical diagnosis of Alzheimer’s disease Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease / Neurology 34:939~944
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
Choi YH / 2006 / Validity of Korean version of the Mini-International Neuropsychiatric Interview / Anxiety Mood 2:50~55
Fischl B / 2002 / Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain / Neuron 33:341~355
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