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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제57권 제1호
발행연도
2016.1
수록면
97 - 102 (6page)

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Purpose: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlyinglung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequentlyin pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. Materials and Methods: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructeda dendrogram for B. cepacia isolates from two children and five adult patients. Results: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children,sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Comparedto children, there were no demonstrative differences in adults, except for history of ICU care. Conclusion: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity.

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