지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 143 - 147 (5page)
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초록· 키워드
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Purpose: Burkholderia cepacia is an aerobic, glucose–non-fermenting, gramnegative bacillus that mainly affects immunocompromised and hospitalized patients. Burkholderia cepacia has high levels of resistance to many antimicrobial agents, and therapeutic options are limited. The authors sought to analyze the incidence, clinical manifestation, risk factors, antimicrobial sensitivity and outcomes of B. cepacia urinary tract infection (UTI) in pediatric patients.
Methods: Pediatric patients with urine culture-proven B. cepacia UTI between January 2000 and December 2014 at Samsung Medical Center, a tertiary referral hospital in Seoul, Republic of Korea, were included in a retrospective analysis of medical records.
Results: Over 14 years, 14 patients (male-to-female ratio of 1:1) were diagnosed with B. cepacia UTI. Of 14 patients with UTI, 11 patients were admitted to the intensive care unit, and a bladder catheter was present in 9 patients when urine culture was positive for B. cepacia. Patients had multiple predisposing factors for UTI, including double-J catheter insertion (14.2%), vesico-ureteral reflux (28. 6%), congenital heart disease (28.6%), or malignancy (21.4%). Burkholderia cepacia isolates were sensitive to piperacillin-tazobactam and sulfamethoxazoletrimethoprim, and resistant to amikacin and colistin. Treatment with parenteral or oral antimicrobial agents including piperacillin-tazobactam, ceftazidime, meropenem, and sulfamethoxazole-trimethoprim resulted in complete recovery from UTI.
Conclusion: Burkholderia cepacia may be a causative pathogen for nosocomial UTI in pediatric patients with predisposing factors, and appropriate selection of antimicrobial therapy is necessary because of high levels of resistance to empirical therapy, including aminoglycosides.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Alvarez-Lerma F / 2008 / Moisturizing body milk as a reservoir of Burkholderia cepacia:outbreak of nosocomial infection in a multidisciplinary intensive care unit / Crit Care
Avgeri SG / 2009 / Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole : a systematic review of the clinical evidence / Int J Antimicrob Agents 33 :
Durham SH / 2012 / Burkholderia cepacia septicemia in a pediatric oncology patient: a pharmacotherapy challenge / Ann Pharmacother 46 : e16 ~
Gravel D / 2002 / Outbreak of burkholderia cepacia in the adult intensive care unit traced to contaminated indigo-carmine dye / Infect Control Hosp Epidemiol 23 : 103 ~ 106
Li FK / 2003 / Burkholderia urinary tract infection after renal transplantation / Transpl Infect Dis 5 : 59 ~ 61
Avgeri SG / 2009 / Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole : a systematic review of the clinical evidence / Int J Antimicrob Agents 33 :
Durham SH / 2012 / Burkholderia cepacia septicemia in a pediatric oncology patient: a pharmacotherapy challenge / Ann Pharmacother 46 : e16 ~
Gravel D / 2002 / Outbreak of burkholderia cepacia in the adult intensive care unit traced to contaminated indigo-carmine dye / Infect Control Hosp Epidemiol 23 : 103 ~ 106
Li FK / 2003 / Burkholderia urinary tract infection after renal transplantation / Transpl Infect Dis 5 : 59 ~ 61
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