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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 249 - 257 (9page)
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초록· 키워드
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Background: The aim of this study is to evaluate the influence of immunosuppressants on in-hospital mortality from sepsis.
Methods: Using data of the Health Insurance Review & Assessment Service, we collected data from patients who were admitted to the hospital due to sepsis from 2009 to 2013. Based on drugs commonly used for immunosuppression caused by various diseases, patients were divided into three groups; immunosuppressant group, steroid-only group, and control group. Patients with no history of immunosuppressants or steroids were assigned to the control group. To identify risk factors of in-hospital mortality in sepsis, we compared differences in patient characteristics, comorbidities, intensive care unit (ICU) care requirements, and immunodeficiency profiles.
Subgroup analysis according to age was also performed.
Results: Of the 185,671 included patients, 13,935 (7.5%) were in the steroid-only group and 2,771 patients (1.5%) were in the immunosuppressant group. The overall in-hospital mortality was 38.9% and showed an increasing trend with age. The steroid-only group showed the lowest in-hospital mortality among the three groups except the patients younger than 30 years. The steroid-only group and immunosuppressant group received ICU treatment more frequently (p < 0.001), stayed longer in the hospital (p < 0.001), and showed higher medical expenditure (p < 0.001) compared to the normal group. Univariate and multivariate analyses revealed that age, male gender, comorbidities (especially malignancy), and ICU treatment had a significant effect on in-hospital mortality.
Conclusions: Despite longer hospital length of stay and more frequent need for ICU care, the in-hospital mortality was lower in patients taking immunosuppressive drugs than in patients not taking immunosuppressive drugs.
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참고문헌 (24)
참고문헌 신청
Bouza E / 2007 / Fever of unknown origin in solid organ transplant recipients / Infect Dis Clin North Am 21 : 1033 ~ 1054
Brun-Buisson C / 1995 / Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU
Buttgereit F / 2005 / Optimised glucocorticoid therapy: the sharpening of an old spear / Lancet 365 : 801 ~ 803
Castellanos-Ortega A / 2010 / Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year fol
Choi NK / 2010 / Signal detection of rosuvastatin compared to other statins: data-mining study using national health insurance claims database / Pharmacoepidemiol Drug Saf 1
Brun-Buisson C / 1995 / Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU
Buttgereit F / 2005 / Optimised glucocorticoid therapy: the sharpening of an old spear / Lancet 365 : 801 ~ 803
Castellanos-Ortega A / 2010 / Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year fol
Choi NK / 2010 / Signal detection of rosuvastatin compared to other statins: data-mining study using national health insurance claims database / Pharmacoepidemiol Drug Saf 1
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