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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 78 - 85 (8page)
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The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (>170U/ml) group (40.1%) was significantly higher than in the low-AGE group (≤170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.
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참고문헌 (15)
참고문헌 신청
/ / Advanced glycation end products in tissue and the biochemical basis of diabetic complications : 1315 ~ 21
/ / Altered cellular interactions between endothelial cells and nonenzymatically glycosylated laminin/type IV collagen : 12404 ~ 7
/ 1997 / Novel analytical approach to monitoring advanced glycosylation end products in human serum with on-line spectrophotometric and spectrofluorometric detection in a fl
/ 1997 / Restenosis rates in diabetic patients a comparison of coronary stenting and balloon angioplasty in native coronary arteries 96 : 1454 ~ 60
/ 1998 / In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia 31 ( ) : 224 ~ 30
/ / Altered cellular interactions between endothelial cells and nonenzymatically glycosylated laminin/type IV collagen : 12404 ~ 7
/ 1997 / Novel analytical approach to monitoring advanced glycosylation end products in human serum with on-line spectrophotometric and spectrofluorometric detection in a fl
/ 1997 / Restenosis rates in diabetic patients a comparison of coronary stenting and balloon angioplasty in native coronary arteries 96 : 1454 ~ 60
/ 1998 / In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia 31 ( ) : 224 ~ 30
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