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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 35 - 39 (5page)
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Purpose: The aim of study was to evaluate the usefulness of serum HER2 as a therapeutic response indicator in patients with HER2 positive metastatic breast cancer (MBC).
Materials and Methods: The levels of serum HER2 and CA15.3 were assayed in 148 serial serum samples from 50 HER2 positive MBC patients at both the baseline and follow-ups. The changes in the levels of serum HER2 and CA15.3 in relation to the tumor responses to the various chemotherapy regimens were monitored.
Results: The levels of serum HER2 and CA15.3 were elevated in 82% and 62% of tissue HER2 positive patients, respectively, prior to therapies, with the changes in both tumor markers showing statistical significance in relation to the tumor responses (p＜0.01) in patients with elevated baseline serum markers.
Conclusion: The level of serum HER2 could be a valuable response indicator, not only for trastuzumab containing therapy, but also for other common MBC chemotherapeutic agents. Also, as it is more frequently elevated, the serum level of HER2 may also be a more useful tumor marker than CA15.3 in HER2 positive MBC. (Cancer Res Treat. 2006;38:35-39)
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참고문헌 (25)
참고문헌 신청
/ 1989 / The neu (c-erbB-2) oncogene 16 : 148 ~ 55
/ 1991 / A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells 6 : 639 ~ 43
/ 1991 / The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells,SK-BR-3 266 : 1716 ~ 20
/ 1992 / Elevated soluble c-erbB-2 antigen levels in the serum and effusions of a proportion of breast cancer patients 10 : 1436 ~ 43
/ 1997 / Influence of circulating c-erbB-2 serum protein on response to adjuvant chemotherapy in node-positive breast cancer patients 43 : 87 ~ 95
/ 1991 / A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells 6 : 639 ~ 43
/ 1991 / The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells,SK-BR-3 266 : 1716 ~ 20
/ 1992 / Elevated soluble c-erbB-2 antigen levels in the serum and effusions of a proportion of breast cancer patients 10 : 1436 ~ 43
/ 1997 / Influence of circulating c-erbB-2 serum protein on response to adjuvant chemotherapy in node-positive breast cancer patients 43 : 87 ~ 95
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