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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 313 - 317 (5page)
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초록· 키워드
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Background: Diabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several populations. This relationship has not been assessed in Jordan. The objective of this study was to investigate the association between serum branched chain amino acids and type 2 diabetes mellitus in patients in Jordan.Methods: Two hundred type 2 diabetes mellitus patients and an additional 200 non-diabetic controls were recruit-ed. Age, body mass index, and waist circumference of the subjects were recorded. Branched chain amino acid, total cholesterol, and triglyceride levels were measured from the collected serum samples.Results: Serum branched chain amino acid levels were significantly higher in type 2 diabetes mellitus patients than in non-diabetes individuals (P<0.0001). In binomial regression analysis, serum branched chain amino acid levels remained significantly associated with diabetes mellitus and increased its risk (odds ratio, 1.004; 95% confidence interval, 1.001–1.006; P=0.003).Conclusion: Type 2 diabetes mellitus is associated with higher branched chain amino acid levels in Jordan indepen-dent of age, sex, body mass index, waist circumference, and total serum cholesterol and serum triglyceride levels.
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참고문헌 (23)
참고문헌 신청
Ogurtsova K / 2017 / IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040 / Diabetes Res Clin Pract 128:40~50
NCD Risk Factor Collaboration (NCD-RisC) / 2016 / Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants / Lancet 387:1513~1530
American Diabetes Association / 2016 / 2. Classification and diagnosis of diabetes / Diabetes Care 39(Suppl 1):S13~S22
Ahima RS / 2015 / Editorial: rethinking the definition of diabetes for precision medicine / Mol Endocrinol 29:335~337
International Diabetes Federation / 2015 / IDF diabetes atlas
NCD Risk Factor Collaboration (NCD-RisC) / 2016 / Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants / Lancet 387:1513~1530
American Diabetes Association / 2016 / 2. Classification and diagnosis of diabetes / Diabetes Care 39(Suppl 1):S13~S22
Ahima RS / 2015 / Editorial: rethinking the definition of diabetes for precision medicine / Mol Endocrinol 29:335~337
International Diabetes Federation / 2015 / IDF diabetes atlas
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