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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 836 - 842 (7page)
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Purpose: This study was undertaken to determine the neuroprotective effect of granulocyte stimulating factor (G-CSF) on neonatal hypoxic-ischemic brain injury. Materials and Methods: Seven-day-old male newborn rat pups were subjected to 110 minutes of 8% oxygen following a unilateral carotid artery ligation. Apoptosis was identified by performing terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining and flow cytometry with a combination of fluorescinated annexin V and propidium iodide (PI) and JC-1 (5,5’,6,6’-tetrachloro-1,1’,3,3’- tetraethylbenzimidazolyl-carbocyanine iodide). The extent of cerebral infarction was evaluated at 2 weeks after recovery. Results: With a single dose (50μg/kg) of G-CSF treatment immediately after hypoxic-ischemic insult, hypoxia-ischemia induced increase in TUNEL-positive cells, annexinV+/PI- and JC-1 positive apoptotic cells in the ipsilateral cerebral cortex was significantly reduced at 24 hours, measured by flow cytometry, and the extent of cerebral infarction at 2 weeks after recovery was also significantly attenuated compared to the hypoxia-ischemia control group. Conclusion: Our data suggest that G-CSF is neuroprotective by inhibiting apoptosis, thereby reducing the ensuing cerebral infarction in a newborn rat pup model of cerebral hypoxia-ischemia (HI).
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참고문헌 (24)
참고문헌 신청
Ahmad M / 2004 / In vivo effect of recombinant human granulocyte colony-s timulating factor on phagocytic function and oxidative burst activity in septic neutropenic neonate
Carr R / 2004 / Haemopoietic growth factors for neonates: assessing risks and benefits / Acta Paediatr 93 : 15 ~ 19
Gibson CL / 2005 / G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice / J Cereb Blood Flow Metab 25 : 431 ~ 439
Gibson CL / 2005 / G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice / J Neuropathol Exp Neurol 64 : 763 ~ 769
Keller M / 2006 / Systemic application of granulocyte- colony stimulating factor and stem cell factor exacerbates excitotoxic brain injury in newborn mice / Pediatr Res 59 (
Carr R / 2004 / Haemopoietic growth factors for neonates: assessing risks and benefits / Acta Paediatr 93 : 15 ~ 19
Gibson CL / 2005 / G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice / J Cereb Blood Flow Metab 25 : 431 ~ 439
Gibson CL / 2005 / G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice / J Neuropathol Exp Neurol 64 : 763 ~ 769
Keller M / 2006 / Systemic application of granulocyte- colony stimulating factor and stem cell factor exacerbates excitotoxic brain injury in newborn mice / Pediatr Res 59 (
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