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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 11 - 18 (8page)
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The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid artery occlusion for 20 min, which was followed by reperfusion for 24 h by restoring the blood flow to the brain. The extent of cerebral injury was assessed after 24 h of global ischemia by measuring the locomotor activity (actophotometer test), motor coordination (inclined beam walking test), neurological severity score, learning and memory (object recognition test) and cerebral infarction (triphenyl tetrazolium chloride stain). Ischemia-reperfusion injury produced significant cerebral infarction, impaired the behavioral parameters and decreased the expression of connexin 43 and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in the brain. A single dose administration of imatinib (20 and 40 mg/kg) attenuated ischemia-reperfusioninduced behavioral deficits and the extent of cerebral infarction along with the restoration of connexin 43 and p-STAT3 levels. However, administration of AG490, a selective Janus-activated kinase 2 (JAK2)/STAT3 inhibitor, abolished the neuroprotective actions of imatinib and decreased the expression of connexin 43 and p-STAT3. It is concluded that imatinib has the potential of attenuating global ischemia-reperfusion- induced cerebral injury, which may be possibly attributed to activation of JAK2/ STAT3 signaling pathway along with the increase in the expression of connexin 43.
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참고문헌 (54)
참고문헌 신청
Baccarani M / 2006 / Evolving concepts in the management of chronic myeloid leukemia : recommendations from an expert panel on behalf of the European LeukemiaNet / Blood 108:1809~1820
Ben Ami E / 2016 / A safety evaluation of imatinib mesylate in the treatment of gastrointestinal stromal tumor / Expert Opin Drug Saf 15:571~578
Kumar M / 2019 / Expanding spectrum of anticancer drug, imatinib, in the disorders affecting brain and spinal cord / Pharmacol Res 143:86~96
Wu R / 2016 / c-Ablp38αsignaling plays an important role in MPTP-induced neuronal death / Cell Death Differ 23:542~552
Cancino GI / 2011 / c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice / Neurobiol Aging 32:1249~1261
Ben Ami E / 2016 / A safety evaluation of imatinib mesylate in the treatment of gastrointestinal stromal tumor / Expert Opin Drug Saf 15:571~578
Kumar M / 2019 / Expanding spectrum of anticancer drug, imatinib, in the disorders affecting brain and spinal cord / Pharmacol Res 143:86~96
Wu R / 2016 / c-Ablp38αsignaling plays an important role in MPTP-induced neuronal death / Cell Death Differ 23:542~552
Cancino GI / 2011 / c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice / Neurobiol Aging 32:1249~1261
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