지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 381 - 386 (6page)
이용수
초록· 키워드
오류제보하기
Objective: To investigate the change of motor evoked potential (MEP) in the cerebral infarction, and observe the effect of stimulation intensity and location of cerebral infarction, using rat model of cerebral ischemia induced by endothelin-1 (ET-1).
Method: Middle cerebral artery (MCA) infarct, cortical infarct, and internal capsular infarct were induced in Spraugue- Dawley rats, by injecting ET-1 stereotaxically. MEP was recorded in forelimb by transcranial magnetic stimulation at 100%, 120%, and 150% of motor threshold by a small figure-8 coil. The location of cerebral infarction was confirmed histologically by 2,3,5-triphenyltetrazolium chloride (TTC) staining.
Results: In MCA infarct, MEP was not recorded at all intensity. In internal capsular infarct, no MEP was recorded at 100% of motor threshold, and amplitude was decreased at 120%. In cortical infarct, MEP was not recorded at 100%, but amplitude was maintained at 120% and 150%. Latency did not change significantly at all intensity.
Conclusion: Amplitude of MEP decreased after cerebral infarction, but latency did not change. Decrease in amplitude was larger with deeper location of cerebral infarction. Cerebral cortex was stimulated at 100% of motor threshold, subcortical structure was stimulated at 120%, and deeper structure was stimulated at 150%, respectively. (J Korean Acad Rehab Med 2010; 34: 381-386)
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Bolay H / 2000 / Altered mechanisms of motor-evoked potential generation after transient focal cerebral ischemia in the rat: implications for transcranial magnetic stimulatio
Chen ST / 1986 / A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction / Stroke 17 : 738 ~ 743
Cicinelli P / 1997 / Post-stroke reorganization of brain motor output to the hand: a 2-4 month follow-up with focal magnetic transcranial stimulation / Electroencephalogr Cli
Cincotta M / 1996 / Hand motor cortex activation in a patient with congenital mirror movements: a study of the silent period following focal transcranial magnetic stimulation
Frost SB / 2006 / An animal model of capsular infarct: endothelin-1 injections in the rat / Behav Brain Res 169 : 206 ~ 211
Chen ST / 1986 / A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction / Stroke 17 : 738 ~ 743
Cicinelli P / 1997 / Post-stroke reorganization of brain motor output to the hand: a 2-4 month follow-up with focal magnetic transcranial stimulation / Electroencephalogr Cli
Cincotta M / 1996 / Hand motor cortex activation in a patient with congenital mirror movements: a study of the silent period following focal transcranial magnetic stimulation
Frost SB / 2006 / An animal model of capsular infarct: endothelin-1 injections in the rat / Behav Brain Res 169 : 206 ~ 211
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