지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Objective : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia, taking into account findings that show 5-hydroxytryptamine-2 receptor blockers can prevent apoptosis. Methods : We created 5 groups, each containing 6 animals. Nothing was done on the K-I group used for comparisons with the other groups to make sure adequate ischemia had been achieved. The K-II group was sacrificed on the 1st day after transient focal cerebral ischemia and the K-III group on the 3rd day. The D-I group was administered quetiapine following ischemia and sacrificed on the 1st day while the D-II group was administered quetiapine every day following the ischemia and sacrificed on the 3rd day. The samples were stained with the immunochemical TUNEL method and the number of apoptotic cells were counted. Results : There was a significant difference between the first and third day control groups (K-II/K-III : p=0.004) and this indicates that apoptotic cell death increases with time. This increase was not encountered in the drug groups (D-I/D-II : p=1.00). Statistical analysis of immunohistochemical data revealed that quetiapine decreased the apoptotic cell death that normally increased with time. Conclusion : Quetiapine is already in clinical use and is a safe drug, in contrast to many substances that are used to prevent ischemia and are not normally used clinically. Our results and the literature data indicate that quetiapine could help both as a neuronal protector and to resolve neuropsychiatric problems caused by the ischemia in cerebral ischemia cases.
목차
등록된 정보가 없습니다.
참고문헌 (73)
참고문헌 신청
Adibhatla RM / 2005 / Cytidine 5’-diphosphocholine (CDP-cho- line) in stroke and other CNS disorders / Neurochem Res 30:15~23
Adibhatla RM / 2002 / Citicoline : neuroprotective mechanisms in cerebral ischemia / J Neurochem 80:12~23
Adibhatla RM / 2004 / Cytidine-5’-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphati- dylcholine after transient brain ischemia / J Neurosci Res 76:390~396
Adibhatla RM / 2003 / Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia / Antioxid Redox Signal 5:647~654
Alkan T / 2001 / Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats / Arch Physiol Biochem 109:135~144
Adibhatla RM / 2002 / Citicoline : neuroprotective mechanisms in cerebral ischemia / J Neurochem 80:12~23
Adibhatla RM / 2004 / Cytidine-5’-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphati- dylcholine after transient brain ischemia / J Neurosci Res 76:390~396
Adibhatla RM / 2003 / Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia / Antioxid Redox Signal 5:647~654
Alkan T / 2001 / Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats / Arch Physiol Biochem 109:135~144
이 논문의 저자 정보
최근 본 자료
댓글(0)
0