지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 508 - 512 (5page)
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초록· 키워드
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Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V. Methods : We preferred in this experimental study a model of global cerebral infarction which was induced by bilateral common carotid artery occlusion method. Rats were randomly divided into 4 groups : sham, ischemia-reperfusion (I/R), I/R plus 20 mg/kg resveratrol and I/R plus 40 mg/kg resveratrol. Statistical analysis was performed using Sigmastat 3.5 ve IBM SPSS Statistics 20. We considered a result significant when p<0.001. Results : After administration of resveratrol, Bcl-2 and Annexin levels were significantly increased (p<0.001). Depending on the dose of resveratrol, Bcl2 levels increased, p53 levels decreased but Annexin V did not effected. P53 levels were significantly increased in ishemia group, so apoptosis is higher compared to other groups. Conclusion : In the acute period, Annexin V levels misleading us because the apoptotic cell counts could not reach a certain level. Therefore we should support our results with bcl-2 and p53.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Aboutaleb N. / 2015 / Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation / J Physiol Sci 65:435~443
Aggarwal BB. / 2004 / Role of resveratrol in prevention and therapy of cancer : preclinical and clinical studies / Anticancer Res 24(5A):2783~2840
최석근 / 2011 / Neuroprotective Effects by Nimodipine Treatment in the Experimental Global Ischemic Rat Model : Real Time Estimation of Glutamate / 대한신경외과학회지 49(1):1~7
de la Lastra CA. / 2007 / Resveratrol as an antioxidant and pro-oxidant agent : mechanisms and clinical implications / Biochem Soc Trans 35(Pt 5):1156~1160
del Zoppo GJ / 1997 / Microvascular responses to cerebral ischemia/inflammation / Ann N Y Acad Sci 823:132~147
Aggarwal BB. / 2004 / Role of resveratrol in prevention and therapy of cancer : preclinical and clinical studies / Anticancer Res 24(5A):2783~2840
최석근 / 2011 / Neuroprotective Effects by Nimodipine Treatment in the Experimental Global Ischemic Rat Model : Real Time Estimation of Glutamate / 대한신경외과학회지 49(1):1~7
de la Lastra CA. / 2007 / Resveratrol as an antioxidant and pro-oxidant agent : mechanisms and clinical implications / Biochem Soc Trans 35(Pt 5):1156~1160
del Zoppo GJ / 1997 / Microvascular responses to cerebral ischemia/inflammation / Ann N Y Acad Sci 823:132~147
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