지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 147 - 153 (7page)
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초록· 키워드
오류제보하기
Objective: To investigate the changes of motor and somatosensory evoked potentials found in focal cerebral cortical ischemia induced by endothelin-1 (ET-1), one of the common models of cerebral infarct in rats.
Method: A total of twenty Sprague-Dawley rats were studied. Focal cerebral cortical ischemia was induced by steterotaxic injection of ET-1 into forelimb region of cerebral cortex. Pellet retrieval test, motor evoked potential (MEP), and somatosensory evoked potential (SEP) were compared before and after cerebral ischemia. The location and extent of cerebral ischemia were confirmed histologically.
Results: Success rate of pellet retrieval test decreased significantly after induction of cerebral ischemia, demonstrating sensorimotor deficit in the contralateral forelimb. The latency and amplitude of MEP did not changed significantly despite weakness of forelimb. However, SEP showed reversal of the positive peaks.
Conclusion: The results suggest that the changes of MEP and SEP in focal cerebral cortical ischemia are different from those in cerebral ischemia by large artery occlusion. When evaluating MEP and SEP in focal cerebral ischemia model, interpretation of evoked potentials should be cautious.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adkins DL / 2005 / d-Amphetamine enhances skilled reaching after ischemic cortical lesions in rats / Neuroscience Letters 380 : 214 ~ 218
Allred RP / 2004 / Unilateral ischemic sensorimotor cortical damage in female rats: forelimb behavioral effects and dendritic structural plasticity in the contralateral homo
Allreda RP / 2004 / Unilateral ischemic sensorimotor cortical damage in female rats: forelimb behavioral effects and dendritic structural plasticity in the contralateral homo
Bolay H / 2000 / Altered mechanisms of motor-evoked potential generation after transient focal cerebral ischemia in the rat: implications for transcranial magnetic stimulati
Borlongan CV / 1995 / Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery / Physiol Behav 58 : 909 ~ 917
Allred RP / 2004 / Unilateral ischemic sensorimotor cortical damage in female rats: forelimb behavioral effects and dendritic structural plasticity in the contralateral homo
Allreda RP / 2004 / Unilateral ischemic sensorimotor cortical damage in female rats: forelimb behavioral effects and dendritic structural plasticity in the contralateral homo
Bolay H / 2000 / Altered mechanisms of motor-evoked potential generation after transient focal cerebral ischemia in the rat: implications for transcranial magnetic stimulati
Borlongan CV / 1995 / Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery / Physiol Behav 58 : 909 ~ 917
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