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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Jae Sung (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Lee, Ho Sung (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Seo, Ki Hyun (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Na, Ju Ock (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Kim, Yong Hoon (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Uh, Soo Taek (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Park, Choon Sik (Department of Internal Medicine, Clinical Research Institute, Soonchunhyang University College of Medicine) Oh, Mee Hye (Department of Pathology, Clinical Research Institute, Soonchunhyang University College of Medicine) Lee, Sang Han (Department of Biochemistry, Clinical Research Institute, Soonchunhyang University College of Medicine) Kim, Young Tong (Department of Radiology, Clinica)
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제73권 제1호
발행연도
2012.1
수록면
22 - 31 (10page)

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Background: Oxidation plays an important role in acute lung injury. This study was conducted in order to elucidate the effect of repetitive post-treatment of N-acetylcysteine (NAC) in lipopolysaccaride (LPS)-induced acute lung injury (ALI) of rats. Methods: Six-week-old male Sprague-Dawley rats were divided into 4 groups. LPS (Escherichia coli 5 mg/kg) was administered intravenously via the tail vein. NAC (20 mg/kg) was injected intraperitoneally 3, 6, and 12 hours after LPS injection. Broncho-alveolar lavage fluid (BALF) and lung tissues were obtained to evaluate the ALI at 24 hours after LPS injection. The concentration of tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$) and interleukin $1{\beta}$ (IL-$1{\beta}$) were measured in BALF. Nuclear factor ${\kappa}B$ (NF-${\kappa}B$), lipid peroxidation (LPO), and myeloperoxidase (MPO) were measured using lung tissues. Micro-computed tomography (micro-CT) images were examined in each group at 72 hours apart from the main experiments in order to observe the delayed effects of NAC. Results: TNF-${\alpha}$ and IL-$1{\beta}$ concentration in BALF were not different between LPS and NAC treatment groups. The concentration of LPO in NAC treatment group was significantly lower than that of LPS group ($5.5{\pm}2.8$ nmol/mL vs. $16.5{\pm}1.6$ nmol/mL) (p=0.001). The activity of MPO in NAC treatment group was significantly lower than that of LPS group ($6.4{\pm}1.8$ unit/g vs. $11.2{\pm}6.3$ unit/g, tissue) (p<0.048). The concentration of NF-${\kappa}B$ in NAC treatment group was significantly lower than that of LPS group ($0.3{\pm}0.1\;ng/{\mu}L$ vs. $0.4{\pm}0.2\;ng/{\mu}L$) (p=0.0001). Micro-CT showed less extent of lung injury in NAC treatment than LPS group. Conclusion: After induction of ALI with lipopolysaccharide, the therapeutic administration of NAC partially attenuated the extent of ALI through the inhibition of NF-${\kappa}B$ activation.
#Acetylcysteine #Acute Lung Injury #Antioxidants

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