지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,214 - 1,221 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Toluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicatedin type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not been completely elucidated. The present study was performed to investigate the role of periostin in TDI-OA. Materials and Methods: Serum periostin levels were measured in subjects with TDI-OA, asymptomatic TDI-exposure controls (AECs), non-occupational asthmatics (NAs), and unexposed normal controls (NCs). To understand the mechanism by which TDI induces periostin production, primary small airway epithelial cells (SAECs) were cultured under stimulation of TDI and neutrophilsfrom asthmatic patients. Results: Fifty-three subjects with TDI-OA, 71 AECs, 67 NAs, and 83 NCs were enrolled. Serum periostin levels were significantly higher in TDI-OA subjects than in AECs (p=0.001), NAs (p<0.001), and NCs (p<0.001). In TDI-exposed subjects (TDI-OA and AEC), the PC20 methacholine levels were significantly lower in subjects with a higher periostin level than in those with a lower periostin level. TDI exposure did not increase periostin production directly by SAECs; however, periostin production increased significantly after co-culture with TDI and neutrophils, which was suppressed by an antioxidant. In addition, increased release of TGF-β1 was noted from SAECs when exposed to TDI and neutrophils, which was also suppressed by an antioxidant. Conclusion: These results suggest that an increased periostin level may contribute to the progression of airway inflammation to remodeling in TDI-exposed workers. A high serum periostin level is a potential serologic marker of the phenotype of TDI-OA.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Cassidy LD / 2017 / Medical monitoring for occupational asthma among toluene diisocyanate production workers in the United States / J Occup Environ Med 59(Suppl 12):S13~S21
Collins JJ / 2017 / Incidence of occupational asthma and exposure to toluene diisocyanate in the United States toluene diisocyanate production industry / J Occup Environ Med 59(Suppl 12):S22~S27
Olivier Vandenplas / 2011 / Occupational Asthma: Etiologies and Risk Factors / Allergy, Asthma & Immunology Research 3(3):157~167
Matteo Ferrando / 2017 / Personalized Medicine in Allergy / Allergy, Asthma & Immunology Research 9(1):15~24
Aleksandra Wardzyńska / 2017 / Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease / Allergy, Asthma & Immunology Research 9(2):126~132
Collins JJ / 2017 / Incidence of occupational asthma and exposure to toluene diisocyanate in the United States toluene diisocyanate production industry / J Occup Environ Med 59(Suppl 12):S22~S27
Olivier Vandenplas / 2011 / Occupational Asthma: Etiologies and Risk Factors / Allergy, Asthma & Immunology Research 3(3):157~167
Matteo Ferrando / 2017 / Personalized Medicine in Allergy / Allergy, Asthma & Immunology Research 9(1):15~24
Aleksandra Wardzyńska / 2017 / Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease / Allergy, Asthma & Immunology Research 9(2):126~132
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease
Allergy, Asthma & Immunology Research
2017 .01
-
Toll-like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Model
Allergy, Asthma & Immunology Research
2020 .01
-
Isoprenaline Induces Periostin Expression in Gastric Cancer
Yonsei Medical Journal
2016 .01
-
The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma
Gut and Liver
2016 .01
-
Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children
Allergy, Asthma & Immunology Research
2018 .01
-
Periostin in Mature Stage Localized Scleroderma
Annals of Dermatology
2017 .06
-
Involvement of Innate Lymphoid Cells and Dendritic Cells in a Mouse Model of Chemical-induced Asthma
Allergy, Asthma & Immunology Research
2021 .01
-
Role of Periostin in Hepatocellular Carcinoma: The Importance of Tumor Microenvironment
Gut and Liver
2016 .01
-
Occupational toluene diisocyanates exposure and cancer mortality : 12-year follow-up study for ten thousand male workers in Korea
대한직업환경의학회 학술대회 논문집
2017 .11
-
Myocardial Tissue Doppler Velocity in Child Growth
Journal of Cardiovascular Imaging
2016 .01
-
Periostin-binding DNA Aptamer Attenuates Diabetic Nephropathy-induced Renal Fibrosis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Serum periostin level and breast cancer progression
환경독성보건학회 심포지엄 및 학술대회
2016 .06
-
아토피피부염 환아에서 혈청 페리오스틴과 편평상피암항원
Allergy Asthma & Respiratory Diseases
2017 .01
-
Early IL-17A Prevention Rather Than Late IL-17A Neutralization Attenuates Toluene Diisocyanate-Induced Mixed Granulocytic Asthma
Allergy, Asthma & Immunology Research
2022 .09
-
소변 중 디아민을 이용한 디이소시아네이트 노출 근로자의 생물학적 모니터링
한국산업보건학회지
2016 .01
-
Development of a Korean Culture-Friendly Olfactory Function Test and Optimization of a Diagnostic Cutoff Value
Clinical and Experimental Otorhinolaryngology
2020 .01
-
Periostin-binding DNA aptamer ameliorates peritoneal dialysis-induced peritoneal fibrosis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
골관절염 대상자의 자기관리 모바일앱 개발을 위한 콘텐츠 요구도 조사
근관절건강학회지
2020 .12
-
The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation
생체재료학회지
2022 .12
-
Osteoarthritis - Insights From Recent Research
대한류마티스학회지
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0