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논문 기본 정보

자료유형
학술저널
저자정보
Han Yin (The First Medical Center Chinese PLA General Hospital PR China.) Muzhe Li (The First Medical Center Chinese PLA General Hospital PR China.) Guangzhao Tian (The First Medical Center Chinese PLA General Hospital PR China.) Yang Ma (The First Medical Center Chinese PLA General Hospital PR China.) Chao Ning (The First Medical Center Chinese PLA General Hospital PR China.) Zineng Yan (The First Medical Center Chinese PLA General Hospital PR China.) Jiang Wu (The First Medical Center Chinese PLA General Hospital PR China.) Qian Ge (Huaiyin People’s Hospital of Huai’an Huai’an 223001 China.) Xiang Sui (The First Medical Center Chinese PLA General Hospital PR China.) Shu-Yun Liu (Institute of Orthopedics of Chinese PLA) Jinxuan Zheng (Sun Yat-Sen University People’s Republic of China.) Weimin Guo (Sun Yat-Sen University Guangdong China) Quan-Yi Guo (Institute of Orthopedics of Chinese PLA)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제26권 제4호
발행연도
2022.12
수록면
756 - 777 (22page)
DOI
https://doi.org/10.1186/s40824-022-00300-7

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Osteoarthritis (OA) is a degenerative joint disease that is common among the middle-aged and older populations, causes patients to experience recurrent pain in their joints and negatively affects their quality of life. Currently, thera peutic options for patients with OA consist of medications to alleviate pain and treat the symptoms; however, due to typically poor outcomes, patients with advanced OA are unlikely to avoid joint replacement. In recent years, several studies have linked disrupted homeostasis of the joint cavity microenvironment to the development of OA. Recently, extracellular vesicles (EVs) have received increasing attention in the field of OA. EVs are natural nano-microcarrier materials with unique biological activity that are produced by cells through paracrine action. They are composed of lipid bilayers that contain physiologically active molecules, such as nucleic acids and proteins. Moreover, EVs may participate in local and distal intercellular and intracellular communication. EVs have also recently been shown to influence OA development by regulating biochemical factors in the OA microenvironmental. In this article, we first describe the microenvironment of OA. Then, we provide an overview of EVs, summarize the main types used for the treatment of OA, and describe their mechanisms. Next, we review clinical studies using EVs for OA treatment. Finally, the specific mechanism underlying the application of miRNA-enriched EVs in OA therapy is described.

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