지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 268 - 275 (8page)
이용수
초록· 키워드
오류제보하기
Background: Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in localized scleroderma are rare. Objective: To investigate the expression of periostin and other molecules in localized scleroderma.
Methods: A retrospective study of 14 patients with confirmed mature stage localized scleroderma was undertaken. Fourteen age-matched and biopsy site-matched subjects with normal skin were included as controls. Collagen fiber deposition, periostin, procollagen, transforming growth factor-β, and matrix metalloproteinase (MMP)-1 expression were assessed and compared between the two groups. Co-localization of α-smooth muscle actin and periostin was evaluated using confocal microscopy. Results: Periostin was predominantly expressed along the dermo-epidermal junction in the controls.
Conversely, patients with localized scleroderma demonstrated increased collagen fiber deposition and periostin expression that was more widely distributed along the entire dermis. MMP-1 staining showed increased expression in the epidermis and dermis of patients compared to scanty expression in the controls. A semi-quantitative evaluation showed a higher proportion of excessive collagen bundle deposition (57.1% vs. 7.1%, p=0.013), diffuse periostin positivity (42.9% vs. 0%, p=0.016), and moderate MMP-1 positivity (71.4% vs. 7.1%, p=0.001) in patients than in the controls. Conclusion: Compared to the controls, patients with localized scleroderma had enhanced periostin expression corresponding to increased collagen fiber deposition and unexpected overexpression of MMP-1. The results of this human in vivo study may implicate the pathogenesis of localized scleroderma.
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등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Takeshita S / 1993 / Osteoblastspecific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I / Biochem J 294:271~278
Kruzynska-Frejtag A / 2004 / Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction / Dev Dyn 229:857~868
Hamilton DW / 2008 / Functional role of periostin in development and wound repair: implications for connective tissue disease / J Cell Commun Signal 2:9~17
Oku E / 2008 / Periostin and bone marrow fibrosis / Int J Hematol 88:57~63
Takeda K / 1994 / Decreased collagenase expression in cultured systemic sclerosis fibroblasts / J Invest Dermatol 103:359~363
Kruzynska-Frejtag A / 2004 / Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction / Dev Dyn 229:857~868
Hamilton DW / 2008 / Functional role of periostin in development and wound repair: implications for connective tissue disease / J Cell Commun Signal 2:9~17
Oku E / 2008 / Periostin and bone marrow fibrosis / Int J Hematol 88:57~63
Takeda K / 1994 / Decreased collagenase expression in cultured systemic sclerosis fibroblasts / J Invest Dermatol 103:359~363
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