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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 948 - 954 (7page)
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초록· 키워드
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Background/Aims: Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses. Methods: We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed. Results: A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years). Conclusions: We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma.
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참고문헌 (23)
참고문헌 신청
Horiuchi K / 1999 / Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta / J Bone Miner Res 14:1239~1249
Takeshita S / 1993 / Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I / Biochem J 294(1):271~278
Litvin J / 2004 / Expression and function of periostin-isoforms in bone / J Cell Biochem 92:1044~1061
Utispan K / 2012 / Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma / Int J Oncol 41:1110~1118
Bao S / 2004 / Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway / Cancer Cell 5:329~339
Takeshita S / 1993 / Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I / Biochem J 294(1):271~278
Litvin J / 2004 / Expression and function of periostin-isoforms in bone / J Cell Biochem 92:1044~1061
Utispan K / 2012 / Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma / Int J Oncol 41:1110~1118
Bao S / 2004 / Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway / Cancer Cell 5:329~339
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