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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제5권 제2호
- 발행연도
- 2017.1
- 수록면
- 73 - 78 (6page)
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초록· 키워드
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Purpose: It was found that periostin and squamous cell carcinoma-related antigens (SCCAs) were strongly interleukin-13-inducible gene products. This study measures the serum periostin and SCCA levels in children suffering from atopic dermatitis (AD) and to evaluate the association between the severity of AD and their values.
Methods: Seventy AD children aged 1 month to 10 years were included in our study. Subjects were characterized as having atopic eczema (AE; n=55) or non-AE (NAE; n=15) by atopic sensitization. Serum SCCA and periostin levels were measured.
Results: The serum periostin levels were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 80.47 ng/mL [75.06–85.93 ng/mL] vs. 67.45 ng/mL [59.99–75.64] ng/mL, P=0.020). The serum concentrations of both SCCA1 and SCCA2 were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 1.401 [1.198–1.643] ng/mL vs. 0.969 [0.723–1.268] ng/mL, P=0.039 for SCCA1) (1.178 [0.974–1.455] ng/mL vs. 0.711 [0.540– 0.994] ng/mL, P=0.025 for SCCA2). The serum periostin levels were significantly correlated with disease severity and with peripheral blood eosinophil counts. The SCCA levels were not significantly correlated with disease severity. Both SCCA1 and SCCA2 were significantly correlated with serum periostin levels and blood eosinophil counts.
Conclusion: Serum periostin levels may be significantly correlated with disease severity and blood eosinophil counts in children with AD. Serum SCCA levels can be significantly correlated with serum periostin levels and blood eosinophil counts in children with AD.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
/ 1993 / Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis / Dermatology 186 : 23 ~ 31
Asher MI / 2006 / Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat mult
Furue M / 1991 / Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis / J Invest Dermatol 96 : 468 ~ 472
Grewe M / 1998 / A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis / Immunol Today 19 : 359 ~ 361
Hamid Q / 1994 / Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis / J Clin Invest 94 : 870 ~ 876
Asher MI / 2006 / Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat mult
Furue M / 1991 / Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis / J Invest Dermatol 96 : 468 ~ 472
Grewe M / 1998 / A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis / Immunol Today 19 : 359 ~ 361
Hamid Q / 1994 / Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis / J Clin Invest 94 : 870 ~ 876
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