지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 942 - 948 (7page)
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초록· 키워드
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Purpose: Forkhead box p3 (Foxp3) positive T regulatory cells (Tregs) have a functionally immunosuppressive property that prevents effector cells from acting against self in autoimmune diseases or a tumor. It is known that Tregs may be highly relevant in cancer progression. Dendritic cells (DCs) induce cutaneous immune response, however several studies have suggested that DCs are involved in immunosuppression. The aim of this study is to evaluate the prevalence of Tregs and DCs infiltration in cutaneous premalignant and malignant squamous lesions. Materials and Methods: We evaluated Tregs and DCs in skin tissue samples obtained from 83 patients with actinic keratosis, Bowen's disease or squamous cell carcinoma by immunohistochemistry. Results: The prevalence of Tregs and DCs was significantly higher in squamous cell carcinoma and Bowen's disease than in actinic keratosis. In addition, the number of DCs was closely correlated with the prevalence of Tregs, and DCs were also located in direct proximity to Tregs. Conclusion: Tregs is related to cutaneous squamous tumor progression.
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참고문헌 (40)
참고문헌 신청
Fontenot JD / 2005 / Regulatory T cell lineage specification by the forkhead transcription factor Foxp3 / Immunity 22:329~341
Chen ML / 2005 / Weissleder R, von Boehmer H, et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-bata signals in vivo / Proc Natl Acad Sci U S A 102:419~424
Onizuka S / 1999 / Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor ɑ) monoclonal antibody / Cancer Res 59:3128~3133
Nishikawa H / 2005 / Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory Tcells in wild-type hosts / Proc Natl Acad Sci U S A 102:9235~9257
Curiel TJ / 2004 / Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival / Nat Med 10:942~949
Chen ML / 2005 / Weissleder R, von Boehmer H, et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-bata signals in vivo / Proc Natl Acad Sci U S A 102:419~424
Onizuka S / 1999 / Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor ɑ) monoclonal antibody / Cancer Res 59:3128~3133
Nishikawa H / 2005 / Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory Tcells in wild-type hosts / Proc Natl Acad Sci U S A 102:9235~9257
Curiel TJ / 2004 / Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival / Nat Med 10:942~949
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