지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제2호
- 발행연도
- 2010.1
- 수록면
- 132 - 140 (9page)
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초록· 키워드
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Background : Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods : Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results : The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions : FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Belkaid Y / 2005 / Natural regulatory T cells in infectious disease / Nat Immunol 6 : 353 ~ 360
Belkaid Y / 2007 / Regulatory T cells and infection:a dangerous necessity / Nat Rev Immunol 7 : 875 ~ 888
Billerbeck E / 2007 / Regulatory T cells in viral hepatitis / World J Gastroenterol 13 : 4858 ~ 4864
Boettler T / 2005 / T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection /
Fontenot JD / 2003 / Foxp3 programs the development and function of CD4+CD25+ regulatory T cells / Nat Immunol 4 : 330 ~ 336
Belkaid Y / 2007 / Regulatory T cells and infection:a dangerous necessity / Nat Rev Immunol 7 : 875 ~ 888
Billerbeck E / 2007 / Regulatory T cells in viral hepatitis / World J Gastroenterol 13 : 4858 ~ 4864
Boettler T / 2005 / T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection /
Fontenot JD / 2003 / Foxp3 programs the development and function of CD4+CD25+ regulatory T cells / Nat Immunol 4 : 330 ~ 336
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