지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제5호
- 발행연도
- 2013.1
- 수록면
- 443 - 451 (9page)
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Background: We examined the distribution of CD8+ T cells and regulatory T cells (Tregs), measured the CD8+ T cell/Tregs ratio, investigated the relationship between Tregs and cyclooxygenase-2 (COX-2) expression during colorectal cancer (CRC) development. Methods: We performed immunohistochemical staining for CD8, forkhead box P3, E-cadherin, and COX-2 in 32 cases of invasive CRC, 10 cases of intramucosal CRC, 27 cases of high-grade tubular adenoma, 22 cases of low-grade tubular adenoma, and 32 cases of non-neoplastic conditions. Results: We observed a progressive increase in Tregs, and a decrease in CD8+ T cells and the CD8+ T cells/Tregs ratio during CRC development. The alterations were most severe in high-grade tubular adenoma and CRC. COX-2 expression was positively associated with Tregs infiltration. The degree of T cell infiltration differed among tumor compartment and the ratio in the tumor center was the lowest of all areas. The ratio and number of CD8+ T cells in the tumor center and the invasive front of invasive CRC were associated with gender, differentiation, node metastasis and tumor budding. Conclusions: Alteration in the distribution of both CD8+T cells and Tregs may contribute to the generation of an immune environment suitable for the development and progression of CRC.
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참고문헌 (25)
참고문헌 신청
Baratelli F / 2005 / Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells / J Immunol 175 : 1483 ~ 1490
Bergmann C / 2007 / Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma / Cancer Re
Boon T / 1994 / Tumor antigens recognized by T lymphocytes / Annu Rev Immunol 12 : 337 ~ 365
Brown JR / 2005 / COX-2: a molecular target for colorectal cancer prevention / J Clin Oncol 23 : 2840 ~ 2855
Deaglio S / 2007 / Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression / J Exp Med 204 : 1257 ~ 1265
Bergmann C / 2007 / Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma / Cancer Re
Boon T / 1994 / Tumor antigens recognized by T lymphocytes / Annu Rev Immunol 12 : 337 ~ 365
Brown JR / 2005 / COX-2: a molecular target for colorectal cancer prevention / J Clin Oncol 23 : 2840 ~ 2855
Deaglio S / 2007 / Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression / J Exp Med 204 : 1257 ~ 1265
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