지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제6호
- 발행연도
- 2010.1
- 수록면
- 581 - 588 (8page)
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초록· 키워드
오류제보하기
Background : Dendritic cells (DCs) play an important role in immune reactions. This study was designed to identify the distribution patterns of DCs and regulatory T-cells (Tregs) in cutaneous lymphomas. Methods : Immunohistochemistry was used to determine langerin expression on Langerhans cells, CD11b on inflammatory DCs, CD209 and CD11c on dermal DCs, CD303 on plasmacytic DCs, and Foxp3 on Tregs in 81 cases of cutaneous lymphomas. Results : Various DCs and Tregs were identified in most cutaneous lymphomas. Plasmacytic DCs, inflammatory DCs and Tregs were identified mainly in tumor areas, whereas dermal DCs were distributed both in the tumor and stromal areas. Among DCs, dermal DCs were most prominently identified in the cutaneous lymphomas not only in the tumor area but also in the stroma. The intense stromal infiltration of dermal DCs was consistent finding in T-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL), not otherwise specified also showed intense stromal infiltration of dermal DCs, but stromal infiltration in DLBCL, leg type was relatively scant. Conclusions : The results suggest that all types of DCs and Tregs are involved in cutaneous lymphoma tumor immunity. Among them dermal DCs may play a dominant role.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Giermasz AS / 2009 / Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines / Cancer Immunol Immunother 58:1329~1336
Wilcox RA / 2009 / Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells / Blood 114:2936~2944
Kutzner H / 2009 / CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma:diagnostic and pathogenetic implications / Am J Surg Pathol 33:1307~1313
Nunez R / 2004 / Functional and structural characterization of two populations of human monocyte-derived dendritic cells / Exp Mol Pathol 77:104~115
Onodera M / 2007 / Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars / Pathol Int 57:337~342
Wilcox RA / 2009 / Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells / Blood 114:2936~2944
Kutzner H / 2009 / CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma:diagnostic and pathogenetic implications / Am J Surg Pathol 33:1307~1313
Nunez R / 2004 / Functional and structural characterization of two populations of human monocyte-derived dendritic cells / Exp Mol Pathol 77:104~115
Onodera M / 2007 / Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars / Pathol Int 57:337~342
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