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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제18권 제4호
- 발행연도
- 2008.1
- 수록면
- 276 - 282 (7page)
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초록· 키워드
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During the last few years, the concept of regulatory T (Treg) cells has received general attention by the scientific community. The activity of Tregs may be critical in the immune outcome to allergen and hence the development of allergic versus nonallergic responses. Two main groups of Treg cell, such as natural Treg cells and inducible Treg cells (Tr1 cells and Th3 cells) have been defined. The search of better Treg cell markers have been continued, and Foxp3, CD25, CD127, folate receptor 4, HLA-DR and CCR 6 could be used. Recent research reveals the cellular and molecular basis of Treg development and function. In allergic diseases, such as asthma, atopic dermatitis and food allergy, many evidences those Treg cells contribute to the control of disease have been showed. This review focuses on current concepts in Treg cell including development, characteristics, cell markers, and cellular and molecular research of Treg cells and Treg cells in allergic diseases. This may be important for advancing our understanding of allergic disease and possible therapeutic applications for the treatment of disease those are associated with a dysfunction in T cell regulation.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Akdis M / 2005 / T regulatory cells in allergy:Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases / J Allergy Clin Immunol 116 : 961 ~ 968
Baecher-Allan C / 2006 / MHC class II expression identifies functionally distinct human regulatory T cells / J Immunol 176 : 4622 ~ 4631
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cell / Nature 441 : 235 ~ 238
Fontenot JD / 2005 / Regulatory T cell lineage specification by the forkhead transcription factor Foxp3 / Immunity 22 : 329 ~ 341
Haribhai D / 2007 / Regulatory T cells dynamically control the primary immune response to foreign antigen / J Immunol 178 : 2961 ~ 2972
Baecher-Allan C / 2006 / MHC class II expression identifies functionally distinct human regulatory T cells / J Immunol 176 : 4622 ~ 4631
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cell / Nature 441 : 235 ~ 238
Fontenot JD / 2005 / Regulatory T cell lineage specification by the forkhead transcription factor Foxp3 / Immunity 22 : 329 ~ 341
Haribhai D / 2007 / Regulatory T cells dynamically control the primary immune response to foreign antigen / J Immunol 178 : 2961 ~ 2972
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