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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 100 - 107 (8page)
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Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis. The intestinal microbiota (IM) has been recently identified as a key player in the severity of liver injury in ALD. Common features of ALD include a decrease of gut epithelial tight junction protein expression, mucin production, and antimicrobial peptide levels. This disruption of the gut barrier, which is a prerequisite for ALD, leads to the passage of bacterial products into the blood stream (endotoxemia). Moreover, metabolites produced by bacteria, such as short chain fatty acids, volatile organic compounds (VOS), and bile acids (BA), are involved in ALD pathology. Probiotic treatment, IM transplantation, or the consumption of dietary fiber, such as pectin, which all alter the ratio of bacterial species, have been shown to improve liver injury in animal models of ALD and to be associated with an improvement in gut barrier function. Although the connections between the microbiota and the host in ALD are well established, the underlying mechanisms are still an active area of research. Targeting the microbiome through the use of prebiotic, probiotic, and postbiotic modalities could be an attractive new approach to manage ALD.
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참고문헌 (62)
참고문헌 신청
Voican CS / 2015 / Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease / Liver Int 35:967~978
European Association For The Study Of The Liver / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Thursz MR / 2015 / Prednisolone or Pentoxifylline for Alcoholic Hepatitis / N Engl J Med 373:282~283
Mathurin P / 2011 / Early liver transplantation for severe alcoholic hepatitis / N Engl J Med 365:1790~1800
Atkinson SR / 2017 / Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis / J Hepatol 67:120~127
European Association For The Study Of The Liver / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Thursz MR / 2015 / Prednisolone or Pentoxifylline for Alcoholic Hepatitis / N Engl J Med 373:282~283
Mathurin P / 2011 / Early liver transplantation for severe alcoholic hepatitis / N Engl J Med 365:1790~1800
Atkinson SR / 2017 / Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis / J Hepatol 67:120~127
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