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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 677 - 685 (9page)
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초록· 키워드
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Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.
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참고문헌 (61)
참고문헌 신청
Merle NS / 2015 / Complement system part II : role in immunity / Front Immunol 6:257
Ricklin D / 2010 / Complement : a key system for immune surveillance and homeostasis / Nat Immunol 11:785~797
Gasque P / 2004 / Complement : a unique innate immune sensor for danger signals / Mol Immunol 41:1089~1098
Fey G / 1981 / Biosynthesis of complement components / Fed Proc 40:2099~2104
Wlazlo N / 2013 / Activated complement factor 3 is associated with liver fat and liver enzymes : the CODAM study / Eur J Clin Invest 43:679~688
Ricklin D / 2010 / Complement : a key system for immune surveillance and homeostasis / Nat Immunol 11:785~797
Gasque P / 2004 / Complement : a unique innate immune sensor for danger signals / Mol Immunol 41:1089~1098
Fey G / 1981 / Biosynthesis of complement components / Fed Proc 40:2099~2104
Wlazlo N / 2013 / Activated complement factor 3 is associated with liver fat and liver enzymes : the CODAM study / Eur J Clin Invest 43:679~688
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