지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 666 - 676 (11page)
- DOI
- 10.5009/gnl20032
이용수
초록· 키워드
오류제보하기
Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of microbial products.
In so-called “leaky gut,” the increased intestinal permeability for bacteria and their products constitutes an important pathogenetic factor for major complications in patients with liver cirrhosis.
Prolonged gastric and small intestinal transit may induce intestinal bacterial overgrowth, a condition in which colonic bacteria translocate into the small gut. Cirrhotic patients further show gut dysbiosis characterized by an overgrowth of potentially pathogenic bacteria and a decrease in autochthonous nonpathogenic bacteria. Pathological bacterial translocation (BT) is a contributing factor in the development of various severe complications. Bile acids (BAs) undergo extensive enterohepatic circulation and play important roles in the gut-liver axis. BT-induced inflammation prevents synthesis of BAs in the liver through inhibition of BA-synthesizing enzyme CYP7A1. A lower abundance of 7α-dehydroxylating gut bacteria leads to decreased conversion of primary to secondary BAs. Decreases in total and secondary BAs may play an important role in the gut dysbiosis characterized by a proinflammatory and toxic gut microbiome inducing BT and endotoxemia, as addressed in my previous reviews. Selective intestinal decontamination by the use of various antimicrobial drugs for management of complications has a long history. Lactobacillus GG decreasing endotoxemia is reported to improve the microbiome with beneficial changes in amino acid, vitamin and secondary BA metabolism. Current approaches for hepatic encephalopathy are the use of nonabsorbable antibiotics and disaccharides. Probiotics may become an additional therapeutic option for advanced liver cirrhosis.
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등록된 정보가 없습니다.
참고문헌 (97)
참고문헌 신청
Pinzani M / 2011 / Liver cirrhosis / Best Pract Res Clin Gastroenterol 25:281~290
Tandon P / 2008 / Bacterial infections, sepsis, and multiorgan failure in cirrhosis / Semin Liver Dis 28:26~42
Arvaniti V / 2010 / Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis / Gastroenterology 139:1246~1256
Pinzone MR / 2012 / Microbial translocation in chronic liver diseases / Int J Microbiol 2012:694629
Bellot P / 2013 / Pathological bacterial translocation in cirrhosis : pathophysiology, diagnosis and clinical implications / Liver Int 33:31~39
Tandon P / 2008 / Bacterial infections, sepsis, and multiorgan failure in cirrhosis / Semin Liver Dis 28:26~42
Arvaniti V / 2010 / Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis / Gastroenterology 139:1246~1256
Pinzone MR / 2012 / Microbial translocation in chronic liver diseases / Int J Microbiol 2012:694629
Bellot P / 2013 / Pathological bacterial translocation in cirrhosis : pathophysiology, diagnosis and clinical implications / Liver Int 33:31~39
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