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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 173 - 188 (16page)
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초록· 키워드
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Alcoholic liver disease (ALD) is a leading cause of cirrhosis, liver cancer, and acute and chronic liver failure and as such causes significant morbidity and mortality. While alcohol consumption is slightly decreasing in several European countries, it is rising in others and remains high in many countries around the world. The pathophysiology of ALD is still incompletely understood but relates largely to the direct toxic effects of alcohol and its main intermediate, acetaldehyde.
Recently, novel putative mechanisms have been identified in systematic scans covering the entire human genome and raise new hypotheses on previously unknown pathways. The latter also identify host genetic risk factors for significant liver injury, which may help design prognostic risk scores. The diagnosis of ALD is relatively easy with a panel of well-evaluated tests and only rarely requires a liver biopsy. Treatment of ALD is difficult and grounded in abstinence as the pivotal therapeutic goal; once cirrhosis is established, treatment largely resembles that of other etiologies of advanced liver damage. Liver transplantation is a sound option for carefully selected patients with cirrhosis and alcoholic hepatitis because relapse rates are low and prognosis is comparable to other etiologies. Still, many countries are restrictive in allocating donor livers for ALD patients. Overall, few therapeutic options exist for severe ALD. However, there is good evidence of benefit for only corticosteroids in severe alcoholic hepatitis, while most other efforts are of limited efficacy. Considering the immense burden of ALD worldwide, efforts of medical professionals and industry partners to develop targeted therapies in ALF has been disappointingly low.
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참고문헌 (26)
참고문헌 신청
Bradford BU / 2005 / Cytochrome P450CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver
Burra P / 2010 / Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry) / Am J Transplant 10 : 138 ~ 148
Case A / 2015 / Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century / Proc Natl Acad Sci U S A 112 : 15078 ~ 15083
Fernandez-Sola J / 2015 / Cardiovascular risks and benefits of moderate and heavy alcohol consumption / Nat Rev Cardiol 12 : 576 ~ 587
Foulds JA / 2015 / Depression in patients with alcohol use disorders: systematic review and meta-analysis of outcomes for independent and substanceinduced disorders / J Affe
Burra P / 2010 / Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry) / Am J Transplant 10 : 138 ~ 148
Case A / 2015 / Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century / Proc Natl Acad Sci U S A 112 : 15078 ~ 15083
Fernandez-Sola J / 2015 / Cardiovascular risks and benefits of moderate and heavy alcohol consumption / Nat Rev Cardiol 12 : 576 ~ 587
Foulds JA / 2015 / Depression in patients with alcohol use disorders: systematic review and meta-analysis of outcomes for independent and substanceinduced disorders / J Affe
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