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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 105 - 111 (7page)
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초록· 키워드
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Purpose: Steroid dependent nephrotic syndrome (SDNS) is a chronic illness in childhood hard to treat. Steroid sparing drugs are often used, because long-term steroid therapy can cause severe side effects. We studied to compare efficacy between MMF and other drugs including cyclosporine and levamisole.
Methods: This study was performed retrospectively on patients with SDNS, who were treated at Pusan National University Children’s hospital. MMF group included 11 patients who were treated with MMF for at least six months between June 2012 and July 2014. As control groups, cyclosporine group (n=15) and levamisole group (n=18) included patients treated between January 2008 and July 2014.
Number of relapse was analyzed in patients treated more than six months, and relapse free for one year was analyzed in patients treated more than one year.
Results: In MMF group, ten were boys and mean age at onset was 5.8 years.
Mean age at starting of MMF was 8.6 years. Number of relapse in MMF group was reduced significantly after treatment from 3.4 /year to 0.2 /year (P=0.003). There was no significant difference in number of relapse among groups (MMF: 0.2 /year, cyclosporine: 0.5 /year, levamisole: 0.5 /year). Comparing the early relapse within six months after treatment levamisole group was significantly higher than the other two groups (P=0.04).
Conclusions: MMF which is used in SDNS significantly reduced the relapse and side effects were rare. In addition, MMF did not show any significant difference in comparison with the other two groups in number of relapse and relapse free for one year.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ 1981 / A report of the international study of kidney disease in children / Kidney Int 20 : 765 ~ 771
Bagga A / 1997 / Levamisole therapy in corticosteroid-dependent nephrotic syndrome / Pediatr Nephrol 11 : 415 ~ 417
Cattran DC / 1999 / A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis / Kidney Int 56 : 2220 ~ 2226
Cheong WY / 2002 / Recent advance in nephrotic syndrome / J Korean Soc Pediatr Nephrol 6 : 15 ~ 24
Dayal U / 1994 / Use of levamisole in maintaining remission in steroid-sensitive nephrotic syndrome in children / Nephron 66 : 408 ~ 412
Bagga A / 1997 / Levamisole therapy in corticosteroid-dependent nephrotic syndrome / Pediatr Nephrol 11 : 415 ~ 417
Cattran DC / 1999 / A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis / Kidney Int 56 : 2220 ~ 2226
Cheong WY / 2002 / Recent advance in nephrotic syndrome / J Korean Soc Pediatr Nephrol 6 : 15 ~ 24
Dayal U / 1994 / Use of levamisole in maintaining remission in steroid-sensitive nephrotic syndrome in children / Nephron 66 : 408 ~ 412
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