지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 160 - 164 (5page)
이용수
초록· 키워드
오류제보하기
C3 glomerulopathy (C3G) is a recently defined pathological entity characterized by C3 accumulation with absent or scant immunoglobulin deposition, leading to variable glomerular inflammation. The clinical presentation of patients with C3G is highly variable, as they may present with symptoms ranging from microscopic or mild proteinuria to full-blown nephrotic syndrome, with or without renal impairment.
However, there is no consensus recommendation for specific treatment in children with C3G. Recently, new therapies have been suggested to target complement pathways, owing to an improvement in the understanding of the pathogenesis of C3G. C3G complement blockade with eculizumab, a monoclonal antibody targeted against complement C5, inhibits activation of the alternative complement pathway. We could not use eculizumab owing to its high price; thus, we administered oral prednisolone and mycophenolate mofetil (MMF). MMF was replaced with cyclosporine because proteinuria persisted, with a consistently low serum C3 level; we tapered off the prednisolone because of a Cushingoid appearance and amenorrhea. Thereafter, proteinuria improved, and the serum C3 level returned to normal. Thus, we report the effectiveness of cyclosporine in a patient with C3G and an inadequate response to prednisolone and MMF, who was detected via school urinary screening.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bagheri N / 2008 / Cyclosporine in the treatment of membranoproliferative glomerulonephritis / Arch Iran Med 11 : 26 ~ 29
Barbour TD / 2013 / Recent insights into C3 glomerulopathy / Nephrol Dial Transplant 28 : 1685 ~ 1693
Bomback AS / 2012 / Pathogenesis of the C3 glomerulopathies and reclassification of MPGN / Nat Rev Nephrol 8 : 634 ~ 642
Cameron JS / 1983 / Idiopathic mesangiocapillary glomerulonephritis. Comparison of types I and II in children and adults and long-term prognosis / Am J Med 74 : 175 ~ 192
Daina E / 2012 / Eculizumab in a Patient with Dense-Deposit Disease / N Engl J Med 366 : 1161 ~ 1163
Barbour TD / 2013 / Recent insights into C3 glomerulopathy / Nephrol Dial Transplant 28 : 1685 ~ 1693
Bomback AS / 2012 / Pathogenesis of the C3 glomerulopathies and reclassification of MPGN / Nat Rev Nephrol 8 : 634 ~ 642
Cameron JS / 1983 / Idiopathic mesangiocapillary glomerulonephritis. Comparison of types I and II in children and adults and long-term prognosis / Am J Med 74 : 175 ~ 192
Daina E / 2012 / Eculizumab in a Patient with Dense-Deposit Disease / N Engl J Med 366 : 1161 ~ 1163
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