지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Rituximab (RTX) is a chimeric monoclonal antibody that inhibits CD20-mediated B-cell proliferation and differentiation. Several studies have examined its use in intractable nephrotic syndrome (NS) with some positive results. However, those studies examined such effects for a short-term period of 1 year, and some patients continued to relapse after a lapse in RTX treatment. Our use of RTX as a maintenance therapy (RTX injection when the CD19 cell count exceeded 100–200/μL before relapse) showed some noticeable efficacy. We used RTX in 19 patients with steroid-dependent NS (SDNS). In 12 patients treated with RTX maintenance therapy, only one relapse occurred. The mean treatment period was 23.4±12.7 months, and the mean number of RTX administrations was 3.9±1.6. The relapse rates were decreased (from 2.68/year to 0.04/year), and the drug-free period also increased (from 22.5 days/year to 357.1 days/year) during maintenance therapy. The other seven patients were treated with one cycle of RTX or additional cycles in case of relapse (non-maintenance therapy). Relapse rates were significantly decreased after RTX treatment (from 1.76/year to 0.96/year, P =0.017). The relapsefree period was 15.55±7.38 (range, 5.3–30.7) months. No severe side effects of RTX were found except for a hypersensitivity reaction such as fever and chills during its infusion. In conclusion, RTX is considered an effective and safe option to reduce the relapse rate by a single- or maintenance-interval therapy in SDNS.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ehrich JHH / 2007 / Steroid-resistant idiopathic childhood nephrosis: overdiagnosed and undertreated / Nephrol Dial Transplant 22:2183~2193
Kyrieleis HAC / 2009 / Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children / Clin J Am Soc Nephrol CJASN 4:1593~1600
Guigonis V / 2008 / RTX treatment for severe steroid- or cyclosporine-dependent nephrotic syndrome: a multicentric series of 22 cases / Pediatr Nephrol 23:1269~1279
Bagga A / 2007 / RTX in patients with the steroidresistant nephrotic syndrome / N Engl J Med 356:2751~2752
Gilbert RD / 2006 / RTX therapy for steroid-dependent minimal change nephrotic syndrome / Pediatr Nephrol 21:1698~1700
Kyrieleis HAC / 2009 / Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children / Clin J Am Soc Nephrol CJASN 4:1593~1600
Guigonis V / 2008 / RTX treatment for severe steroid- or cyclosporine-dependent nephrotic syndrome: a multicentric series of 22 cases / Pediatr Nephrol 23:1269~1279
Bagga A / 2007 / RTX in patients with the steroidresistant nephrotic syndrome / N Engl J Med 356:2751~2752
Gilbert RD / 2006 / RTX therapy for steroid-dependent minimal change nephrotic syndrome / Pediatr Nephrol 21:1698~1700
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