메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Sung-Eun Choi (Chonnam National University Hospital Chonnam National University Medical School) Dong-Jin Park (Department of Rheumatology Chonnam National University Hospital) Ji-Hyoun Kang (Chonnam National University Hospital Chonnam National University Medical School) Kyung-Eun Lee (Chonnam National University Medical School & Hospital Gwangju Korea) Haimuzi Xu (Division of Rheumatology Department of Internal Medicine Chonnam National University Medical School) Ji Shin Lee (Departments of Pathology Chonnam National University Medical School Gwangju Korea) Yoo Duk Choi (Dept. of Pathology Chonnam National University Medical School) Shin-Seok Lee (Division of Rheumatology Department of Internal Medicine Chonnam National University Hospital)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제26권 제1호
발행연도
2019.1
수록면
57 - 65 (9page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objective. Although intravenous cyclophosphamide (IVC) is generally accepted as the standard therapy for induction treatment of active proliferative lupus nephritis (LN), several clinical trials have suggested that mycophenolate mofetil (MMF) is at least as effective as IVC. Because few Asian studies have compared the two treatment modalities, we compared the efficacies of MMF and IVC as LN remission induction treatments in Korean patients. Methods. We enrolled 39 patients with class III and IV LN who received MMF or IVC as LN induction therapy. The renal outcomes (i.e., complete response [CR], partial response [PR], and no response [NR]) at 6 and 12 months were defined using the ACR 2006 response criteria. Results. Of 39 patients, 23 (59.0%) were treated with IVC, and 16 (41.0%) were treated with MMF. Demographics, clinical characteristics, laboratory data, and adverse events did not significantly differ between the two groups. However, C3 levels were lower and activity scores in renal biopsy were higher in IVC-treated patients. CRs were achieved by 11 (47.8%) of the patients receiving IVC and 7 (43.8%) of the patients receiving MMF after 6 months of treatment (p=0.961) and by 11 (47.8%) of those who received IVC and 9 (56.2%) of those who received MMF at 12 months of treatment (p=0.713). Neither the PR rate nor the NR rate differed significantly at 6 or 12 months between the two groups. Conclusion. The efficacy of MMF does not differ from that of IVC in terms of induction of LN remission in Korean patients.
#Lupus nephritis #Cyclophosphamide #Mycophenolic acid #Induction of remission

목차

등록된 정보가 없습니다.

참고문헌 (28)

참고문헌 신청
Tsokos GC / 2011 / Systemic lupus erythematosus / N Engl J Med 365:2110~2121 google schola Illei GG / 2001 / Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis / Ann Intern Med 135:248~257 google schola Mok CC / 2013 / Anti-müllerian hormone and ovarian reserve in systemic lupus erythematosus / Arthritis Rheum 65:206~210 google schola Ginzler EM / 2005 / Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis / N Engl J Med 353:2219~2228 google schola Kamanamool N / 2010 / Efficacy and adverse events of mycophenolate mofetil versus cyclophosphamide for induction therapy of lupus nephritis: systematic review and meta-analysis / Medicine 89:227~235 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0